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Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands.
Petronilho EC, Pedrote MM, Marques MA, Passos YM, Mota MF, Jakobus B, de Sousa GDS, Pereira da Costa F, Felix AL, Ferretti GDS, Almeida FP, Cordeiro Y, Vieira TCRG, de Oliveira GAP, Silva JL. Petronilho EC, et al. Among authors: silva jl. Chem Sci. 2021 Apr 26;12(21):7334-7349. doi: 10.1039/d1sc01739j. Chem Sci. 2021. PMID: 34163823 Free PMC article.
Fibrillar aggregates of the tumor suppressor p53 core domain.
Ishimaru D, Andrade LR, Teixeira LS, Quesado PA, Maiolino LM, Lopez PM, Cordeiro Y, Costa LT, Heckl WM, Weissmüller G, Foguel D, Silva JL. Ishimaru D, et al. Among authors: silva jl. Biochemistry. 2003 Aug 5;42(30):9022-7. doi: 10.1021/bi034218k. Biochemistry. 2003. PMID: 12885235
903 results