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Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators.
Huppertsberg A, Kaps L, Zhong Z, Schmitt S, Stickdorn J, Deswarte K, Combes F, Czysch C, De Vrieze J, Kasmi S, Choteschovsky N, Klefenz A, Medina-Montano C, Winterwerber P, Chen C, Bros M, Lienenklaus S, Sanders NN, Koynov K, Schuppan D, Lambrecht BN, David SA, De Geest BG, Nuhn L. Huppertsberg A, et al. Among authors: david sa. J Am Chem Soc. 2021 Jul 7;143(26):9872-9883. doi: 10.1021/jacs.1c03772. Epub 2021 Jun 24. J Am Chem Soc. 2021. PMID: 34166595 Free PMC article.
pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation.
Nuhn L, Vanparijs N, De Beuckelaer A, Lybaert L, Verstraete G, Deswarte K, Lienenklaus S, Shukla NM, Salyer AC, Lambrecht BN, Grooten J, David SA, De Koker S, De Geest BG. Nuhn L, et al. Among authors: david sa. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8098-103. doi: 10.1073/pnas.1600816113. Epub 2016 Jul 5. Proc Natl Acad Sci U S A. 2016. PMID: 27382168 Free PMC article.
Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles.
Wang B, Van Herck S, Chen Y, Bai X, Zhong Z, Deswarte K, Lambrecht BN, Sanders NN, Lienenklaus S, Scheeren HW, David SA, Kiessling F, Lammers T, De Geest BG, Shi Y. Wang B, et al. Among authors: david sa. J Am Chem Soc. 2020 Jul 15;142(28):12133-12139. doi: 10.1021/jacs.0c01928. Epub 2020 Jun 30. J Am Chem Soc. 2020. PMID: 32524819 Free PMC article.
Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy.
Li H, Van Herck S, Liu Y, Hao Y, Ding X, Nuhn L, Zhong Z, Combes F, Sanders NN, Lienenklaus S, Koker SD, David SA, Wang Y, De Geest BG, Zhang Z. Li H, et al. Among authors: david sa. ACS Biomater Sci Eng. 2020 Sep 14;6(9):4993-5000. doi: 10.1021/acsbiomaterials.0c00485. Epub 2020 Aug 11. ACS Biomater Sci Eng. 2020. PMID: 33455292
Lipid-Polyglutamate Nanoparticle Vaccine Platform.
Van Lysebetten D, Malfanti A, Deswarte K, Koynov K, Golba B, Ye T, Zhong Z, Kasmi S, Lamoot A, Chen Y, Van Herck S, Lambrecht BN, Sanders NN, Lienenklaus S, David SA, Vicent MJ, De Koker S, De Geest BG. Van Lysebetten D, et al. Among authors: david sa. ACS Appl Mater Interfaces. 2021 Feb 10;13(5):6011-6022. doi: 10.1021/acsami.0c20607. Epub 2021 Jan 28. ACS Appl Mater Interfaces. 2021. PMID: 33507728 Free PMC article.
120 results