Fransson R - Search Results

1

Characterisation of pharmacokinetics, safety and tolerability in a first-in-human study for AZD8154, a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease.

Sadiq MW, Asimus S, Belvisi MG, Brailsford W, Fransson R, Fuhr R, Hagberg A, Hashemi M, Jellesmark Jensen T, Jonsson J, Keen C, Körnicke T, Kristensson C, Mäenpää J, Necander S, Nemes S, Betts J. Sadiq MW, et al. Among authors: fransson r. Br J Clin Pharmacol. 2022 Jan;88(1):260-270. doi: 10.1111/bcp.14956. Epub 2021 Aug 8. Br J Clin Pharmacol. 2022. PMID: 34182611 Free article. Clinical Trial.

2

Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.

Perry MWD, Björhall K, Bold P, Brűlls M, Börjesson U, Carlsson J, Chang HA, Chen Y, Eriksson A, Fihn BM, Fransson R, Fredlund L, Ge H, Huang H, Karabelas K, Lamm Bergström E, Lever S, Lindmark H, Mogemark M, Nikitidis A, Palmgren AP, Pemberton N, Petersen J, Rodrigo Blomqvist M, Smith RW, Thomas MJ, Ullah V, Tyrchan C, Wennberg T, Westin Eriksson A, Yang W, Zhao S, Öster L. Perry MWD, et al. Among authors: fransson r. J Med Chem. 2021 Jun 24;64(12):8053-8075. doi: 10.1021/acs.jmedchem.1c00434. Epub 2021 Jun 3. J Med Chem. 2021. PMID: 34080862

3

Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs.

Frenning G, van der Zwaan I, Franek F, Fransson R, Tehler U. Frenning G, et al. Among authors: fransson r. Mol Pharm. 2020 Jul 6;17(7):2426-2434. doi: 10.1021/acs.molpharmaceut.0c00163. Epub 2020 Jun 15. Mol Pharm. 2020. PMID: 32463245 Free PMC article.

4

Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.

Fransson R, Botros M, Sköld C, Nyberg F, Lindeberg G, Hallberg M, Sandström A. Fransson R, et al. J Med Chem. 2010 Mar 25;53(6):2383-9. doi: 10.1021/jm901352b. J Med Chem. 2010. PMID: 20178322

5

Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.

Ortqvist P, Peterson SD, Kerblom E, Gossas T, Sabnis YA, Fransson R, Lindeberg G, Helena Danielson U, Karlén A, Sandström A. Ortqvist P, et al. Among authors: fransson r. Bioorg Med Chem. 2007 Feb 1;15(3):1448-74. doi: 10.1016/j.bmc.2006.11.003. Epub 2006 Nov 6. Bioorg Med Chem. 2007. PMID: 17113777

6

Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability.

Fransson R, Sköld C, Kratz JM, Svensson R, Artursson P, Nyberg F, Hallberg M, Sandström A. Fransson R, et al. J Med Chem. 2013 Jun 27;56(12):4953-65. doi: 10.1021/jm400209h. Epub 2013 Jun 17. J Med Chem. 2013. PMID: 23735006 Free article.

7

An imidazole based H-Phe-Phe-NH₂ peptidomimetic with anti-allodynic effect in spared nerve injury mice.

Skogh A, Lesniak A, Sköld C, Karlgren M, Gaugaz FZ, Svensson R, Diwakarla S, Jonsson A, Fransson R, Nyberg F, Hallberg M, Sandström A. Skogh A, et al. Among authors: fransson r. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2446-2450. doi: 10.1016/j.bmcl.2018.06.009. Epub 2018 Jun 15. Bioorg Med Chem Lett. 2018. PMID: 29929882

8

Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model.

van der Zwaan I, Franek F, Fransson R, Tehler U, Frenning G. van der Zwaan I, et al. Among authors: fransson r. Mol Pharm. 2022 Sep 5;19(9):3114-3124. doi: 10.1021/acs.molpharmaceut.2c00177. Epub 2022 Aug 8. Mol Pharm. 2022. PMID: 35939615 Free PMC article.

9

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues.

Fransson R, Nordvall G, Bylund J, Carlsson-Jonsson A, Kratz JM, Svensson R, Artursson P, Hallberg M, Sandström A. Fransson R, et al. ACS Med Chem Lett. 2014 Oct 29;5(12):1272-7. doi: 10.1021/ml5002954. eCollection 2014 Dec 11. ACS Med Chem Lett. 2014. PMID: 25516784 Free PMC article.

10

Aminocarbonylation of 4-iodo-1H-imidazoles with an amino acid amide nucleophile: synthesis of constrained H-Phe-Phe-NH2 analogues.

Skogh A, Fransson R, Sköld C, Larhed M, Sandström A. Skogh A, et al. Among authors: fransson r. J Org Chem. 2013 Dec 6;78(23):12251-6. doi: 10.1021/jo4020613. Epub 2013 Nov 14. J Org Chem. 2013. PMID: 24171628

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