Sharlow ER - Search Results

1

Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer.

Lazo JS, Sharlow ER, Cornelison R, Hart DJ, Llaneza DC, Mendelson AJ, Rastelli EJ, Tasker NR, Landen CN Jr, Wipf P. Lazo JS, et al. Among authors: sharlow er. Biomolecules. 2021 Jun 30;11(7):969. doi: 10.3390/biom11070969. Biomolecules. 2021. PMID: 34209460 Free PMC article.

2

Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1.

Sharlow ER, Leimgruber S, Shun TY, Lazo JS. Sharlow ER, et al. Assay Drug Dev Technol. 2007 Dec;5(6):723-35. doi: 10.1089/adt.2007.102. Assay Drug Dev Technol. 2007. PMID: 18181689 Free PMC article.

3

Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries.

Sharlow ER, Leimgruber S, Yellow-Duke A, Barrett R, Wang QJ, Lazo JS. Sharlow ER, et al. Nat Protoc. 2008;3(8):1350-63. doi: 10.1038/nprot.2008.111. Nat Protoc. 2008. PMID: 18714303

4

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.

Sharlow ER, Giridhar KV, LaValle CR, Chen J, Leimgruber S, Barrett R, Bravo-Altamirano K, Wipf P, Lazo JS, Wang QJ. Sharlow ER, et al. J Biol Chem. 2008 Nov 28;283(48):33516-26. doi: 10.1074/jbc.M805358200. Epub 2008 Sep 30. J Biol Chem. 2008. PMID: 18829454 Free PMC article.

5

A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

Wipf P, Arnold D, Carter K, Dong S, Johnston PA, Sharlow E, Lazo JS, Huryn D. Wipf P, et al. Curr Top Med Chem. 2009;9(13):1194-205. doi: 10.2174/156802609789753590. Curr Top Med Chem. 2009. PMID: 19807663 Review.

6

Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen.

Sharlow ER, Close D, Shun T, Leimgruber S, Reed R, Mustata G, Wipf P, Johnson J, O'Neil M, Grögl M, Magill AJ, Lazo JS. Sharlow ER, et al. PLoS Negl Trop Dis. 2009 Nov 3;3(11):e540. doi: 10.1371/journal.pntd.0000540. PLoS Negl Trop Dis. 2009. PMID: 19888337 Free PMC article.

7

Anti-leishmanial drug discovery: rising to the challenges of a highly neglected disease.

Sharlow ER, Grögl M, Johnson J, Lazo JS. Sharlow ER, et al. Mol Interv. 2010 Apr;10(2):72-5. doi: 10.1124/mi.10.2.4. Mol Interv. 2010. PMID: 20368366 Review. No abstract available.

8

A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.

Sharlow ER, Lyda TA, Dodson HC, Mustata G, Morris MT, Leimgruber SS, Lee KH, Kashiwada Y, Close D, Lazo JS, Morris JC. Sharlow ER, et al. PLoS Negl Trop Dis. 2010 Apr 13;4(4):e659. doi: 10.1371/journal.pntd.0000659. PLoS Negl Trop Dis. 2010. PMID: 20405000 Free PMC article.

9

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility.

Lavalle CR, Bravo-Altamirano K, Giridhar KV, Chen J, Sharlow E, Lazo JS, Wipf P, Wang QJ. Lavalle CR, et al. BMC Chem Biol. 2010 May 5;10:5. doi: 10.1186/1472-6769-10-5. BMC Chem Biol. 2010. PMID: 20444281 Free PMC article.

10

Protein kinase D as a potential new target for cancer therapy.

LaValle CR, George KM, Sharlow ER, Lazo JS, Wipf P, Wang QJ. LaValle CR, et al. Among authors: sharlow er. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. doi: 10.1016/j.bbcan.2010.05.003. Epub 2010 May 24. Biochim Biophys Acta. 2010. PMID: 20580776 Free PMC article. Review.

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