Luk KC - Search Results

1

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples.

Puentes LN, Lengyel-Zhand Z, Lee JY, Hsieh CJ, Schneider ME Jr, Edwards KJ, Luk KC, Lee VM, Trojanowski JQ, Mach RH. Puentes LN, et al. Among authors: luk kc. Front Aging Neurosci. 2021 Jun 18;13:704041. doi: 10.3389/fnagi.2021.704041. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34220490 Free PMC article.

2

Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors.

Luk KC, Hyde EG, Trojanowski JQ, Lee VM. Luk KC, et al. Biochemistry. 2007 Nov 6;46(44):12522-9. doi: 10.1021/bi701128c. Epub 2007 Oct 10. Biochemistry. 2007. PMID: 17927212

3

Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.

Luk KC, Mills IP, Trojanowski JQ, Lee VM. Luk KC, et al. Biochemistry. 2008 Nov 25;47(47):12614-25. doi: 10.1021/bi801475r. Biochemistry. 2008. PMID: 18975920 Free PMC article.

4

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells.

Luk KC, Song C, O'Brien P, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM. Luk KC, et al. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20051-6. doi: 10.1073/pnas.0908005106. Epub 2009 Nov 5. Proc Natl Acad Sci U S A. 2009. PMID: 19892735 Free PMC article.

5

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.

Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM. Volpicelli-Daley LA, et al. Among authors: luk kc. Neuron. 2011 Oct 6;72(1):57-71. doi: 10.1016/j.neuron.2011.08.033. Neuron. 2011. PMID: 21982369 Free PMC article.

6

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.

Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Luk KC, et al. J Exp Med. 2012 May 7;209(5):975-86. doi: 10.1084/jem.20112457. Epub 2012 Apr 16. J Exp Med. 2012. PMID: 22508839 Free PMC article.

7

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice.

Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Luk KC, et al. Science. 2012 Nov 16;338(6109):949-53. doi: 10.1126/science.1227157. Science. 2012. PMID: 23161999 Free PMC article.

8

Modeling Lewy pathology propagation in Parkinson's disease.

Luk KC, Lee VM. Luk KC, et al. Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1(0 1):S85-7. doi: 10.1016/S1353-8020(13)70022-1. Parkinsonism Relat Disord. 2014. PMID: 24262196 Free PMC article. Review.

9

Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.

Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM. Tran HT, et al. Among authors: luk kc. Cell Rep. 2014 Jun 26;7(6):2054-65. doi: 10.1016/j.celrep.2014.05.033. Epub 2014 Jun 12. Cell Rep. 2014. PMID: 24931606 Free PMC article.

10

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.

Volpicelli-Daley LA, Luk KC, Lee VM. Volpicelli-Daley LA, et al. Among authors: luk kc. Nat Protoc. 2014 Sep;9(9):2135-46. doi: 10.1038/nprot.2014.143. Epub 2014 Aug 14. Nat Protoc. 2014. PMID: 25122523 Free PMC article.

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