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Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.
Mathsyaraja H, Catchpole J, Freie B, Eastwood E, Babaeva E, Geuenich M, Cheng PF, Ayers J, Yu M, Wu N, Moorthi S, Poudel KR, Koehne A, Grady W, Houghton AM, Berger AH, Shiio Y, MacPherson D, Eisenman RN. Mathsyaraja H, et al. Among authors: eastwood e. Elife. 2021 Jul 8;10:e64212. doi: 10.7554/eLife.64212. Elife. 2021. PMID: 34236315 Free PMC article.
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity.
Grunblatt E, Wu N, Zhang H, Liu X, Norton JP, Ohol Y, Leger P, Hiatt JB, Eastwood EC, Thomas R, Ibrahim AH, Jia D, Basom R, Eaton KD, Martins R, Houghton AM, MacPherson D. Grunblatt E, et al. Among authors: eastwood ec. Genes Dev. 2020 Sep 1;34(17-18):1210-1226. doi: 10.1101/gad.340133.120. Epub 2020 Aug 20. Genes Dev. 2020. PMID: 32820040 Free PMC article.
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.
Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D. Augert A, et al. Among authors: eastwood e. Sci Signal. 2019 Feb 5;12(567):eaau2922. doi: 10.1126/scisignal.aau2922. Sci Signal. 2019. PMID: 30723171 Free PMC article.
Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.
Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D. Jia D, et al. Among authors: eastwood e. Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4. Cancer Discov. 2018. PMID: 30181244 Free PMC article.
47 results