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Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
Ding J, Gumpena R, Boily MO, Caron A, Chong O, Cox JH, Dumais V, Gaudreault S, Graff AH, King A, Knight J, Oballa R, Surendradoss J, Tang T, Wu J, Lowther WT, Powell DA. Ding J, et al. Among authors: knight j. ACS Med Chem Lett. 2021 May 20;12(7):1116-1123. doi: 10.1021/acsmedchemlett.1c00196. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267881 Free PMC article.
Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
Li X, Knight J, Fargue S, Buchalski B, Guan Z, Inscho EW, Liebow A, Fitzgerald K, Querbes W, Todd Lowther W, Holmes RP. Li X, et al. Among authors: knight j. Biochim Biophys Acta. 2016 Feb;1862(2):233-9. doi: 10.1016/j.bbadis.2015.12.001. Epub 2015 Dec 2. Biochim Biophys Acta. 2016. PMID: 26655602 Free PMC article.
The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria.
Buchalski B, Wood KD, Challa A, Fargue S, Holmes RP, Lowther WT, Knight J. Buchalski B, et al. Among authors: knight j. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165633. doi: 10.1016/j.bbadis.2019.165633. Epub 2019 Dec 7. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 31821850 Free PMC article.
End Points for Clinical Trials in Primary Hyperoxaluria.
Milliner DS, McGregor TL, Thompson A, Dehmel B, Knight J, Rosskamp R, Blank M, Yang S, Fargue S, Rumsby G, Groothoff J, Allain M, West M, Hollander K, Lowther WT, Lieske JC. Milliner DS, et al. Among authors: knight j. Clin J Am Soc Nephrol. 2020 Jul 1;15(7):1056-1065. doi: 10.2215/CJN.13821119. Epub 2020 Mar 12. Clin J Am Soc Nephrol. 2020. PMID: 32165440 Free PMC article.
3,403 results