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Page 1
Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.
Yang Y, Csakai A, Jiang S, Smith C, Tanji H, Huang J, Jones T, Sakaniwa K, Broadwell L, Shi C, Soti S, Ohto U, Fang Y, Shen S, Deng F, Shimizu T, Yin H. Yang Y, et al. Among authors: sakaniwa k. Nat Commun. 2021 Jul 16;12(1):4351. doi: 10.1038/s41467-021-24536-4. Nat Commun. 2021. PMID: 34272380 Free PMC article.
Small-molecule inhibition of TLR8 through stabilization of its resting state.
Zhang S, Hu Z, Tanji H, Jiang S, Das N, Li J, Sakaniwa K, Jin J, Bian Y, Ohto U, Shimizu T, Yin H. Zhang S, et al. Among authors: sakaniwa k. Nat Chem Biol. 2018 Jan;14(1):58-64. doi: 10.1038/nchembio.2518. Epub 2017 Nov 20. Nat Chem Biol. 2018. PMID: 29155428 Free PMC article.
Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.
Hu Z, Tanji H, Jiang S, Zhang S, Koo K, Chan J, Sakaniwa K, Ohto U, Candia A, Shimizu T, Yin H. Hu Z, et al. Among authors: sakaniwa k. Cell Chem Biol. 2018 Oct 18;25(10):1286-1291.e3. doi: 10.1016/j.chembiol.2018.07.004. Epub 2018 Aug 9. Cell Chem Biol. 2018. PMID: 30100350 Free PMC article.