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Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.
Prekovic S, Schuurman K, Mayayo-Peralta I, Manjón AG, Buijs M, Yavuz S, Wellenstein MD, Barrera A, Monkhorst K, Huber A, Morris B, Lieftink C, Chalkiadakis T, Alkan F, Silva J, Győrffy B, Hoekman L, van den Broek B, Teunissen H, Debets DO, Severson T, Jonkers J, Reddy T, de Visser KE, Faller W, Beijersbergen R, Altelaar M, de Wit E, Medema R, Zwart W. Prekovic S, et al. Among authors: faller w. Nat Commun. 2021 Jul 16;12(1):4360. doi: 10.1038/s41467-021-24537-3. Nat Commun. 2021. PMID: 34272384 Free PMC article.
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium; van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ. Leach JDG, et al. Among authors: faller wj. Nat Commun. 2021 Jun 8;12(1):3464. doi: 10.1038/s41467-021-23717-5. Nat Commun. 2021. PMID: 34103493 Free PMC article.
Oncogene-dependent sloppiness in mRNA translation.
Champagne J, Pataskar A, Blommaert N, Nagel R, Wernaart D, Ramalho S, Kenski J, Bleijerveld OB, Zaal EA, Berkers CR, Altelaar M, Peeper DS, Faller WJ, Agami R. Champagne J, et al. Mol Cell. 2021 Nov 18;81(22):4709-4721.e9. doi: 10.1016/j.molcel.2021.09.002. Epub 2021 Sep 24. Mol Cell. 2021. PMID: 34562372 Free article.
Identifying ribosome heterogeneity using ribosome profiling.
Alkan F, Wilkins OG, Hernández-Pérez S, Ramalho S, Silva J, Ule J, Faller WJ. Alkan F, et al. Nucleic Acids Res. 2022 Sep 9;50(16):e95. doi: 10.1093/nar/gkac484. Nucleic Acids Res. 2022. PMID: 35687114 Free PMC article.
Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation.
Silva J, Alkan F, Ramalho S, Snieckute G, Prekovic S, Garcia AK, Hernández-Pérez S, van der Kammen R, Barnum D, Hoekman L, Altelaar M, Zwart W, Suijkerbuijk SJE, Bekker-Jensen S, Faller WJ. Silva J, et al. Among authors: faller wj. Nat Commun. 2022 Aug 2;13(1):4492. doi: 10.1038/s41467-022-32220-4. Nat Commun. 2022. PMID: 35918345 Free PMC article.
The histone methyltransferase SETD2 negatively regulates cell size.
Molenaar TM, Malik M, Silva J, Liu NQ, Haarhuis JHI, Ambrosi C, Kwesi-Maliepaard EM, van Welsem T, Baubec T, Faller WJ, van Leeuwen F. Molenaar TM, et al. J Cell Sci. 2022 Oct 1;135(19):jcs259856. doi: 10.1242/jcs.259856. Epub 2022 Oct 6. J Cell Sci. 2022. PMID: 36052643 Free PMC article.
NAC regulates metabolism and cell fate in intestinal stem cells.
Ramalho S, Alkan F, Prekovic S, Jastrzebski K, Barberà EP, Hoekman L, Altelaar M, de Heus C, Liv N, Rodríguez-Colman MJ, Yilmaz M, van der Kammen R, Fedry J, de Gooijer MC, Suijkerbuijk SJE, Faller WJ, Silva J. Ramalho S, et al. Among authors: faller wj. Sci Adv. 2025 Jan 10;11(2):eadn9750. doi: 10.1126/sciadv.adn9750. Epub 2025 Jan 8. Sci Adv. 2025. PMID: 39772672 Free PMC article.
Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells.
Huels DJ, Bruens L, Hodder MC, Cammareri P, Campbell AD, Ridgway RA, Gay DM, Solar-Abboud M, Faller WJ, Nixon C, Zeiger LB, McLaughlin ME, Morrissey E, Winton DJ, Snippert HJ, van Rheenen J, Sansom OJ. Huels DJ, et al. Among authors: faller wj. Nat Commun. 2018 Mar 19;9(1):1132. doi: 10.1038/s41467-018-03426-2. Nat Commun. 2018. PMID: 29556067 Free PMC article.
49 results