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21 results

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Page 1
Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods.
Klapars A, Chung JYL, Limanto J, Calabria R, Campeau LC, Campos KR, Chen W, Dalby SM, Davis TA, DiRocco DA, Hyde AM, Kassim AM, Larsen MU, Liu G, Maligres PE, Moment A, Peng F, Ruck RT, Shevlin M, Simmons BL, Song ZJ, Tan L, Wright TJ, Zultanski SL. Klapars A, et al. Among authors: maligres pe. Chem Sci. 2021 May 19;12(26):9031-9036. doi: 10.1039/d1sc01978c. eCollection 2021 Jul 7. Chem Sci. 2021. PMID: 34276931 Free PMC article.
A multifunctional catalyst that stereoselectively assembles prodrugs.
DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW. DiRocco DA, et al. Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936. Science. 2017. PMID: 28450641
Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates.
Christensen M, Nolting A, Shevlin M, Weisel M, Maligres PE, Lee J, Orr RK, Plummer CW, Tudge MT, Campeau LC, Ruck RT. Christensen M, et al. Among authors: maligres pe. J Org Chem. 2016 Feb 5;81(3):824-30. doi: 10.1021/acs.joc.5b02296. Epub 2016 Jan 25. J Org Chem. 2016. PMID: 26743694
Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19.
McIntosh JA, Benkovics T, Silverman SM, Huffman MA, Kong J, Maligres PE, Itoh T, Yang H, Verma D, Pan W, Ho HI, Vroom J, Knight AM, Hurtak JA, Klapars A, Fryszkowska A, Morris WJ, Strotman NA, Murphy GS, Maloney KM, Fier PS. McIntosh JA, et al. Among authors: maligres pe. ACS Cent Sci. 2021 Dec 22;7(12):1980-1985. doi: 10.1021/acscentsci.1c00608. Epub 2021 Oct 29. ACS Cent Sci. 2021. PMID: 34963891 Free PMC article.
Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454.
Benkovics T, Peng F, Phillips EM, An C, Bade RS, Chung CK, Dance ZEX, Fier PS, Forstater JH, Liu Z, Liu Z, Maligres PE, Marshall NM, Salehi Marzijarani N, McIntosh JA, Miller SP, Moore JC, Neel AJ, Obligacion JV, Pan W, Pirnot MT, Poirier M, Reibarkh M, Sherry BD, Song ZJ, Tan L, Turnbull BWH, Verma D, Waldman JH, Wang L, Wang T, Winston MS, Xu F. Benkovics T, et al. Among authors: maligres pe. J Am Chem Soc. 2022 Apr 6;144(13):5855-5863. doi: 10.1021/jacs.1c12106. Epub 2022 Mar 25. J Am Chem Soc. 2022. PMID: 35333525
Enantioselective synthesis of an HCV NS5a antagonist.
Mangion IK, Chen CY, Li H, Maligres P, Chen Y, Christensen M, Cohen R, Jeon I, Klapars A, Krska S, Nguyen H, Reamer RA, Sherry BD, Zavialov I. Mangion IK, et al. Org Lett. 2014 May 2;16(9):2310-3. doi: 10.1021/ol500971c. Epub 2014 Apr 11. Org Lett. 2014. PMID: 24724971
Asymmetric synthesis of cyclic indole aminals via 1,3-stereoinduction.
Li H, Chen CY, Nguyen H, Cohen R, Maligres PE, Yasuda N, Mangion I, Zavialov I, Reibarkh M, Chung JY. Li H, et al. Among authors: maligres pe. J Org Chem. 2014 Sep 19;79(18):8533-40. doi: 10.1021/jo501581e. Epub 2014 Sep 3. J Org Chem. 2014. PMID: 25162915
21 results