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FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase.
Voisin J, Farina F, Naphade S, Fontaine M, Tshilenge KT, Galicia Aguirre C, Lopez-Ramirez A, Dancourt J, Ginisty A, Sasidharan Nair S, Lakshika Madushani K, Zhang N, Lejeune FX, Verny M, Campisi J, Ellerby LM, Neri C. Voisin J, et al. Among authors: ellerby lm. Aging Cell. 2020 Nov;19(11):e13226. doi: 10.1111/acel.13226. Epub 2020 Nov 6. Aging Cell. 2020. PMID: 33156570 Free PMC article.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, Ehrlich ME, Ellerby LM. Bailus BJ, et al. Among authors: ellerby lm. Autophagy. 2021 Dec;17(12):4119-4140. doi: 10.1080/15548627.2021.1904489. Epub 2021 May 24. Autophagy. 2021. PMID: 34024231 Free PMC article.
Calpain activation in Huntington's disease.
Gafni J, Ellerby LM. Gafni J, et al. Among authors: ellerby lm. J Neurosci. 2002 Jun 15;22(12):4842-9. doi: 10.1523/JNEUROSCI.22-12-04842.2002. J Neurosci. 2002. PMID: 12077181 Free PMC article.
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. Hermel E, et al. Among authors: ellerby lm, ellerby hm. Cell Death Differ. 2004 Apr;11(4):424-38. doi: 10.1038/sj.cdd.4401358. Cell Death Differ. 2004. PMID: 14713958
112 results