Lepšík M - Search Results

1

3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.

Dayal N, Řezníčková E, Hernandez DE, Peřina M, Torregrosa-Allen S, Elzey BD, Škerlová J, Ajani H, Djukic S, Vojáčková V, Lepšík M, Řezáčová P, Kryštof V, Jorda R, Sintim HO. Dayal N, et al. Among authors: lepsik m. J Med Chem. 2021 Aug 12;64(15):10981-10996. doi: 10.1021/acs.jmedchem.1c00330. Epub 2021 Jul 21. J Med Chem. 2021. PMID: 34288692

2

A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution.

Brynda J, Rezacova P, Fabry M, Horejsi M, Stouracova R, Sedlacek J, Soucek M, Hradilek M, Lepsik M, Konvalinka J. Brynda J, et al. Among authors: lepsik m. J Med Chem. 2004 Apr 8;47(8):2030-6. doi: 10.1021/jm031105q. J Med Chem. 2004. PMID: 15056001

3

Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir.

Sasková KG, Kozísek M, Lepsík M, Brynda J, Rezácová P, Václavíková J, Kagan RM, Machala L, Konvalinka J. Sasková KG, et al. Among authors: lepsik m. Protein Sci. 2008 Sep;17(9):1555-64. doi: 10.1110/ps.036079.108. Epub 2008 Jun 17. Protein Sci. 2008. PMID: 18560011 Free PMC article.

4

Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.

Kozísek M, Cígler P, Lepsík M, Fanfrlík J, Rezácová P, Brynda J, Pokorná J, Plesek J, Grüner B, Grantz Sasková K, Václavíková J, Král V, Konvalinka J. Kozísek M, et al. Among authors: lepsik m. J Med Chem. 2008 Aug 14;51(15):4839-43. doi: 10.1021/jm8002334. Epub 2008 Jul 4. J Med Chem. 2008. PMID: 18598016

5

Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes.

Rezácová P, Pokorná J, Brynda J, Kozísek M, Cígler P, Lepsík M, Fanfrlík J, Rezác J, Grantz Sasková K, Sieglová I, Plesek J, Sícha V, Grüner B, Oberwinkler H, Sedlácek' J, Kräusslich HG, Hobza P, Král V, Konvalinka J. Rezácová P, et al. Among authors: lepsik m. J Med Chem. 2009 Nov 26;52(22):7132-41. doi: 10.1021/jm9011388. J Med Chem. 2009. PMID: 19874035

6

Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni.

Jílková A, Řezáčová P, Lepšík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mareš M. Jílková A, et al. Among authors: lepsik m. J Biol Chem. 2011 Oct 14;286(41):35770-35781. doi: 10.1074/jbc.M111.271304. Epub 2011 Aug 10. J Biol Chem. 2011. PMID: 21832058 Free PMC article.

7

Aurora kinase inhibitors: progress towards the clinic.

Kollareddy M, Zheleva D, Dzubak P, Brahmkshatriya PS, Lepsik M, Hajduch M. Kollareddy M, et al. Among authors: lepsik m. Invest New Drugs. 2012 Dec;30(6):2411-32. doi: 10.1007/s10637-012-9798-6. Epub 2012 Feb 18. Invest New Drugs. 2012. PMID: 22350019 Free PMC article. Review.

8

Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.

Schimer J, Cígler P, Veselý J, Grantz Šašková K, Lepšík M, Brynda J, Rezáčová P, Kožíšek M, Císařová I, Oberwinkler H, Kraeusslich HG, Konvalinka J. Schimer J, et al. Among authors: lepsik m. J Med Chem. 2012 Nov 26;55(22):10130-5. doi: 10.1021/jm301249q. Epub 2012 Oct 23. J Med Chem. 2012. PMID: 23050738

9

Quantum mechanics-based scoring rationalizes the irreversible inactivation of parasitic Schistosoma mansoni cysteine peptidase by vinyl sulfone inhibitors.

Fanfrlík J, Brahmkshatriya PS, Řezáč J, Jílková A, Horn M, Mareš M, Hobza P, Lepšík M. Fanfrlík J, et al. Among authors: lepsik m. J Phys Chem B. 2013 Dec 5;117(48):14973-82. doi: 10.1021/jp409604n. Epub 2013 Nov 21. J Phys Chem B. 2013. PMID: 24195769

10

QM/MM calculations reveal the different nature of the interaction of two carborane-based sulfamide inhibitors of human carbonic anhydrase II.

Pecina A, Lepšík M, Řezáč J, Brynda J, Mader P, Řezáčová P, Hobza P, Fanfrlík J. Pecina A, et al. Among authors: lepsik m. J Phys Chem B. 2013 Dec 19;117(50):16096-104. doi: 10.1021/jp410216m. Epub 2013 Dec 11. J Phys Chem B. 2013. PMID: 24289143

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