Vallelian F - Search Results

1

Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics.

Buzzi RM, Owczarek CM, Akeret K, Tester A, Pereira N, Butcher R, Brügger-Verdon V, Hardy MP, Illi M, Wassmer A, Vallelian F, Humar R, Hugelshofer M, Buehler PW, Gentinetta T, Schaer DJ. Buzzi RM, et al. Among authors: vallelian f. Mol Pharm. 2021 Aug 2;18(8):3158-3170. doi: 10.1021/acs.molpharmaceut.1c00433. Epub 2021 Jul 22. Mol Pharm. 2021. PMID: 34292741 Free article.

2

CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system.

Schaer CA, Vallelian F, Imhof A, Schoedon G, Schaer DJ. Schaer CA, et al. Among authors: vallelian f. J Leukoc Biol. 2007 Jul;82(1):106-10. doi: 10.1189/jlb.0706453. Epub 2007 Apr 25. J Leukoc Biol. 2007. PMID: 17460152

3

Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation.

Schaer CA, Vallelian F, Imhof A, Schoedon G, Schaer DJ. Schaer CA, et al. Among authors: vallelian f. J Leukoc Biol. 2008 Feb;83(2):325-33. doi: 10.1189/jlb.0407226. Epub 2007 Oct 18. J Leukoc Biol. 2008. PMID: 17947394

4

Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways.

Buehler PW, Vallelian F, Mikolajczyk MG, Schoedon G, Schweizer T, Alayash AI, Schaer DJ. Buehler PW, et al. Among authors: vallelian f. Antioxid Redox Signal. 2008 Aug;10(8):1449-62. doi: 10.1089/ars.2008.2028. Antioxid Redox Signal. 2008. PMID: 18522492

5

The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways.

Vallelian F, Pimenova T, Pereira CP, Abraham B, Mikolajczyk MG, Schoedon G, Zenobi R, Alayash AI, Buehler PW, Schaer DJ. Vallelian F, et al. Free Radic Biol Med. 2008 Oct 15;45(8):1150-8. doi: 10.1016/j.freeradbiomed.2008.07.013. Epub 2008 Jul 27. Free Radic Biol Med. 2008. PMID: 18708138

6

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification.

Buehler PW, Abraham B, Vallelian F, Linnemayr C, Pereira CP, Cipollo JF, Jia Y, Mikolajczyk M, Boretti FS, Schoedon G, Alayash AI, Schaer DJ. Buehler PW, et al. Among authors: vallelian f. Blood. 2009 Mar 12;113(11):2578-86. doi: 10.1182/blood-2008-08-174466. Epub 2009 Jan 8. Blood. 2009. PMID: 19131549 Free article.

7

Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase.

Widmer CC, Pereira CP, Gehrig P, Vallelian F, Schoedon G, Buehler PW, Schaer DJ. Widmer CC, et al. Among authors: vallelian f. Antioxid Redox Signal. 2010 Feb;12(2):185-98. doi: 10.1089/ars.2009.2826. Antioxid Redox Signal. 2010. PMID: 19702440 Free article.

8

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity.

Vallelian F, Schaer CA, Kaempfer T, Gehrig P, Duerst E, Schoedon G, Schaer DJ. Vallelian F, et al. Blood. 2010 Dec 9;116(24):5347-56. doi: 10.1182/blood-2010-04-277319. Epub 2010 Aug 25. Blood. 2010. PMID: 20739658 Free article.

9

Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression.

Kaempfer T, Duerst E, Gehrig P, Roschitzki B, Rutishauser D, Grossmann J, Schoedon G, Vallelian F, Schaer DJ. Kaempfer T, et al. Among authors: vallelian f. J Proteome Res. 2011 May 6;10(5):2397-408. doi: 10.1021/pr101230y. Epub 2011 Apr 14. J Proteome Res. 2011. PMID: 21405025

10

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW. Baek JH, et al. Among authors: vallelian f. J Clin Invest. 2012 Apr;122(4):1444-58. doi: 10.1172/JCI59770. Epub 2012 Mar 26. J Clin Invest. 2012. PMID: 22446185 Free PMC article.

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