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AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.
Xu J, Yu X, Martin TC, Bansal A, Cheung K, Lubin A, Stratikopoulos E, Cahuzac KM, Wang L, Xie L, Zhou R, Shen Y, Wu X, Yao S, Qiao R, Poulikakos PI, Chen X, Liu J, Jin J, Parsons R. Xu J, et al. Among authors: poulikakos pi. Cancer Discov. 2021 Dec 1;11(12):3064-3089. doi: 10.1158/2159-8290.CD-20-0815. Cancer Discov. 2021. PMID: 34301793 Free PMC article.
Mutant BRAF melanomas--dependence and resistance.
Poulikakos PI, Rosen N. Poulikakos PI, et al. Cancer Cell. 2011 Jan 18;19(1):11-5. doi: 10.1016/j.ccr.2011.01.008. Cancer Cell. 2011. PMID: 21251612 Free article. Review.
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling.
Rodrik-Outmezguine VS, Chandarlapaty S, Pagano NC, Poulikakos PI, Scaltriti M, Moskatel E, Baselga J, Guichard S, Rosen N. Rodrik-Outmezguine VS, et al. Among authors: poulikakos pi. Cancer Discov. 2011 Aug;1(3):248-59. doi: 10.1158/2159-8290.CD-11-0085. Epub 2011 Jun 17. Cancer Discov. 2011. PMID: 22140653 Free PMC article.
New perspectives for targeting RAF kinase in human cancer.
Karoulia Z, Gavathiotis E, Poulikakos PI. Karoulia Z, et al. Among authors: poulikakos pi. Nat Rev Cancer. 2017 Nov;17(11):676-691. doi: 10.1038/nrc.2017.79. Epub 2017 Oct 6. Nat Rev Cancer. 2017. PMID: 28984291 Free PMC article. Review.
Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents.
Stratikopoulos EE, Kiess N, Szabolcs M, Pegno S, Kakit C, Wu X, Poulikakos PI, Cheung P, Schmidt H, Parsons R. Stratikopoulos EE, et al. Among authors: poulikakos pi. Oncogene. 2019 Jan;38(1):47-59. doi: 10.1038/s41388-018-0436-4. Epub 2018 Aug 3. Oncogene. 2019. PMID: 30076411 Free PMC article.
Global view of the RAF-MEK-ERK module and its immediate downstream effectors.
Santini CC, Longden J, Schoof EM, Simpson CD, Jeschke GR, Creixell P, Kim J, Wu X, Turk BE, Rosen N, Poulikakos PI, Linding R. Santini CC, et al. Among authors: poulikakos pi. Sci Rep. 2019 Jul 26;9(1):10865. doi: 10.1038/s41598-019-47245-x. Sci Rep. 2019. PMID: 31350469 Free PMC article.
44 results