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Page 1
Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis.
Gangoda L, Schenk RL, Best SA, Nedeva C, Louis C, D'Silva DB, Fairfax K, Jarnicki AG, Puthalakath H, Sutherland KD, Strasser A, Herold MJ. Gangoda L, et al. Among authors: schenk rl. Cell Death Differ. 2022 Jan;29(1):96-104. doi: 10.1038/s41418-021-00839-3. Epub 2021 Jul 24. Cell Death Differ. 2022. PMID: 34304242 Free PMC article.
Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.
Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM. Carrington EM, et al. Among authors: schenk rl. Cell Death Differ. 2017 May;24(5):878-888. doi: 10.1038/cdd.2017.30. Epub 2017 Mar 31. Cell Death Differ. 2017. PMID: 28362427 Free PMC article.
BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia.
Carrington EM, Louis C, Kratina T, Hancock M, Keenan CR, Iannarella N, Allan RS, Wardak AZ, Czabotar PE, Herold MJ, Schenk RL, White CA, D'Silva D, Yang Y, Wong W, Wong H, Bryant VL, Huntington ND, Rautela J, Sutherland RM, Zhan Y, Hansen J, Nhu D, Lessene G, Wicks IP, Lew AM. Carrington EM, et al. Among authors: schenk rl. Blood Adv. 2021 Jun 8;5(11):2550-2562. doi: 10.1182/bloodadvances.2020004139. Blood Adv. 2021. PMID: 34100903 Free PMC article.
Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs.
Gangoda L, Schenk RL, Tai L, Szeto P, Cheung JG, Strasser A, Lessene G, Shackleton M, Herold MJ. Gangoda L, et al. Among authors: schenk rl. Cell Death Dis. 2022 Apr 4;13(4):301. doi: 10.1038/s41419-022-04776-y. Cell Death Dis. 2022. PMID: 35379799 Free PMC article. No abstract available.
DNA repair processes are critical mediators of p53-dependent tumor suppression.
Janic A, Valente LJ, Wakefield MJ, Di Stefano L, Milla L, Wilcox S, Yang H, Tai L, Vandenberg CJ, Kueh AJ, Mizutani S, Brennan MS, Schenk RL, Lindqvist LM, Papenfuss AT, O'Connor L, Strasser A, Herold MJ. Janic A, et al. Among authors: schenk rl. Nat Med. 2018 Jul;24(7):947-953. doi: 10.1038/s41591-018-0043-5. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892060
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