Gervasio FL - Search Results

1

Structural basis of the effect of activating mutations on the EGF receptor.

Galdadas I, Carlino L, Ward RA, Hughes SJ, Haider S, Gervasio FL. Galdadas I, et al. Among authors: gervasio fl. Elife. 2021 Jul 28;10:e65824. doi: 10.7554/eLife.65824. Elife. 2021. PMID: 34319231 Free PMC article.

2

Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase.

Sutto L, Gervasio FL. Sutto L, et al. Among authors: gervasio fl. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10616-21. doi: 10.1073/pnas.1221953110. Epub 2013 Jun 10. Proc Natl Acad Sci U S A. 2013. PMID: 23754386 Free PMC article.

3

Modeling the effect of pathogenic mutations on the conformational landscape of protein kinases.

Saladino G, Gervasio FL. Saladino G, et al. Among authors: gervasio fl. Curr Opin Struct Biol. 2016 Apr;37:108-14. doi: 10.1016/j.sbi.2016.01.005. Epub 2016 Jan 26. Curr Opin Struct Biol. 2016. PMID: 26820051 Review.

4

Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations.

Kuzmanic A, Sutto L, Saladino G, Nebreda AR, Gervasio FL, Orozco M. Kuzmanic A, et al. Among authors: gervasio fl. Elife. 2017 Apr 26;6:e22175. doi: 10.7554/eLife.22175. Elife. 2017. PMID: 28445123 Free PMC article.

5

Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance.

Galdadas I, Lovera S, Pérez-Hernández G, Barnes MD, Healy J, Afsharikho H, Woodford N, Bonomo RA, Gervasio FL, Haider S. Galdadas I, et al. Among authors: gervasio fl. Sci Rep. 2018 Aug 27;8(1):12916. doi: 10.1038/s41598-018-31176-0. Sci Rep. 2018. PMID: 30150677 Free PMC article.

6

Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer.

Martin-Fernandez ML, Clarke DT, Roberts SK, Zanetti-Domingues LC, Gervasio FL. Martin-Fernandez ML, et al. Among authors: gervasio fl. Cells. 2019 Apr 5;8(4):316. doi: 10.3390/cells8040316. Cells. 2019. PMID: 30959819 Free PMC article. Review.

7

A combined activation mechanism for the glucagon receptor.

Mattedi G, Acosta-Gutiérrez S, Clark T, Gervasio FL. Mattedi G, et al. Among authors: gervasio fl. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15414-15422. doi: 10.1073/pnas.1921851117. Epub 2020 Jun 22. Proc Natl Acad Sci U S A. 2020. PMID: 32571939 Free PMC article.

8

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics.

Galdadas I, Qu S, Oliveira ASF, Olehnovics E, Mack AR, Mojica MF, Agarwal PK, Tooke CL, Gervasio FL, Spencer J, Bonomo RA, Mulholland AJ, Haider S. Galdadas I, et al. Among authors: gervasio fl. Elife. 2021 Mar 23;10:e66567. doi: 10.7554/eLife.66567. Elife. 2021. PMID: 33755013 Free PMC article.

9

Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant.

Ilmjärv S, Abdul F, Acosta-Gutiérrez S, Estarellas C, Galdadas I, Casimir M, Alessandrini M, Gervasio FL, Krause KH. Ilmjärv S, et al. Among authors: gervasio fl. Sci Rep. 2021 Jul 1;11(1):13705. doi: 10.1038/s41598-021-91662-w. Sci Rep. 2021. PMID: 34210996 Free PMC article.

10

Unravelling the effect of the E545K mutation on PI3Kα kinase.

Galdadas I, Gervasio FL, Cournia Z. Galdadas I, et al. Among authors: gervasio fl. Chem Sci. 2020 Feb 26;11(13):3511-3515. doi: 10.1039/c9sc05903b. eCollection 2020 Apr 7. Chem Sci. 2020. PMID: 34703536 Free PMC article.

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