Shewmaker F - Search Results

1

The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation.

Owen I, Yee D, Wyne H, Perdikari TM, Johnson V, Smyth J, Kortum R, Fawzi NL, Shewmaker F. Owen I, et al. Among authors: shewmaker f. J Cell Sci. 2021 Sep 1;134(17):jcs258578. doi: 10.1242/jcs.258578. Epub 2021 Sep 3. J Cell Sci. 2021. PMID: 34357401 Free PMC article.

2

The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions.

Owen I, Rhoads S, Yee D, Wyne H, Gery K, Hannula I, Sundrum M, Shewmaker F. Owen I, et al. Among authors: shewmaker f. Mol Biol Cell. 2020 Nov 1;31(23):2522-2536. doi: 10.1091/mbc.E20-05-0290. Epub 2020 Sep 2. Mol Biol Cell. 2020. PMID: 32877292 Free PMC article.

3

N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein fused in sarcoma.

Bock AS, Murthy AC, Tang WS, Jovic N, Shewmaker F, Mittal J, Fawzi NL. Bock AS, et al. Among authors: shewmaker f. Protein Sci. 2021 Jul;30(7):1337-1349. doi: 10.1002/pro.4029. Epub 2021 Mar 6. Protein Sci. 2021. PMID: 33547841 Free PMC article.

4

The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization.

Rhoads SN, Monahan ZT, Yee DS, Leung AY, Newcombe CG, O'Meally RN, Cole RN, Shewmaker FP. Rhoads SN, et al. Among authors: shewmaker fp. Mol Biol Cell. 2018 Aug 1;29(15):1786-1797. doi: 10.1091/mbc.E17-12-0735. Epub 2018 Jun 13. Mol Biol Cell. 2018. PMID: 29897835 Free PMC article.

5

The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS.

Rhoads SN, Monahan ZT, Yee DS, Shewmaker FP. Rhoads SN, et al. Int J Mol Sci. 2018 Mar 16;19(3):886. doi: 10.3390/ijms19030886. Int J Mol Sci. 2018. PMID: 29547565 Free PMC article. Review.

6

Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.

Monahan Z, Ryan VH, Janke AM, Burke KA, Rhoads SN, Zerze GH, O'Meally R, Dignon GL, Conicella AE, Zheng W, Best RB, Cole RN, Mittal J, Shewmaker F, Fawzi NL. Monahan Z, et al. Among authors: shewmaker f. EMBO J. 2017 Oct 16;36(20):2951-2967. doi: 10.15252/embj.201696394. Epub 2017 Aug 8. EMBO J. 2017. PMID: 28790177 Free PMC article.

7

The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins.

Owen I, Shewmaker F. Owen I, et al. Among authors: shewmaker f. Int J Mol Sci. 2019 Nov 5;20(21):5501. doi: 10.3390/ijms20215501. Int J Mol Sci. 2019. PMID: 31694155 Free PMC article. Review.

8

A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL. Wang A, et al. Among authors: shewmaker f. EMBO J. 2018 Mar 1;37(5):e97452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9. EMBO J. 2018. PMID: 29438978 Free PMC article.

9

DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner.

Fortuna TR, Kour S, Anderson EN, Ward C, Rajasundaram D, Donnelly CJ, Hermann A, Wyne H, Shewmaker F, Pandey UB. Fortuna TR, et al. Among authors: shewmaker f. Acta Neuropathol. 2021 Sep;142(3):515-536. doi: 10.1007/s00401-021-02333-z. Epub 2021 Jun 1. Acta Neuropathol. 2021. PMID: 34061233 Free PMC article.

10

Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms.

Monahan ZT, Rhoads SN, Yee DS, Shewmaker FP. Monahan ZT, et al. Among authors: shewmaker fp. Front Mol Neurosci. 2018 Dec 11;11:453. doi: 10.3389/fnmol.2018.00453. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30618605 Free PMC article. Review.

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