Neckers LM - Search Results

1

Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.

Liu L, Deng Y, Zheng Z, Deng Z, Zhang J, Li J, Liang M, Zhou X, Tan W, Yang H, Neckers LM, Zou F, Chen X. Liu L, et al. Among authors: neckers lm. Mol Cancer Ther. 2021 Oct;20(10):1880-1892. doi: 10.1158/1535-7163.MCT-21-0215. Epub 2021 Aug 10. Mol Cancer Ther. 2021. PMID: 34376581 Free PMC article.

2

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW, Mitchell JB, Neckers LM, Gius D. Bisht KS, et al. Among authors: neckers lm. Cancer Res. 2003 Dec 15;63(24):8984-95. Cancer Res. 2003. PMID: 14695217

3

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

Mimnaugh EG, Xu W, Vos M, Yuan X, Isaacs JS, Bisht KS, Gius D, Neckers L. Mimnaugh EG, et al. Mol Cancer Ther. 2004 May;3(5):551-66. Mol Cancer Ther. 2004. PMID: 15141013

4

Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.

Xu W, Yuan X, Beebe K, Xiang Z, Neckers L. Xu W, et al. Mol Cell Biol. 2007 Jan;27(1):220-8. doi: 10.1128/MCB.00899-06. Epub 2006 Oct 9. Mol Cell Biol. 2007. PMID: 17030621 Free PMC article.

5

An acetylation site in the middle domain of Hsp90 regulates chaperone function.

Scroggins BT, Robzyk K, Wang D, Marcu MG, Tsutsumi S, Beebe K, Cotter RJ, Felts S, Toft D, Karnitz L, Rosen N, Neckers L. Scroggins BT, et al. Mol Cell. 2007 Jan 12;25(1):151-9. doi: 10.1016/j.molcel.2006.12.008. Mol Cell. 2007. PMID: 17218278 Free PMC article.

6

Heat shock protein 90: the cancer chaperone.

Neckers L. Neckers L. J Biosci. 2007 Apr;32(3):517-30. doi: 10.1007/s12038-007-0051-y. J Biosci. 2007. PMID: 17536171 Review.

7

Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis.

Tsutsumi S, Neckers L. Tsutsumi S, et al. Cancer Sci. 2007 Oct;98(10):1536-9. doi: 10.1111/j.1349-7006.2007.00561.x. Epub 2007 Jul 23. Cancer Sci. 2007. PMID: 17645779 Free PMC article. Review.

8

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition.

Xu W, Soga S, Beebe K, Lee MJ, Kim YS, Trepel J, Neckers L. Xu W, et al. Br J Cancer. 2007 Sep 17;97(6):741-4. doi: 10.1038/sj.bjc.6603950. Epub 2007 Aug 21. Br J Cancer. 2007. PMID: 17712310 Free PMC article.

9

A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion.

Tsutsumi S, Scroggins B, Koga F, Lee MJ, Trepel J, Felts S, Carreras C, Neckers L. Tsutsumi S, et al. Oncogene. 2008 Apr 10;27(17):2478-87. doi: 10.1038/sj.onc.1210897. Epub 2007 Oct 29. Oncogene. 2008. PMID: 17968312 Free PMC article.

10

Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells.

Neckers L, Kern A, Tsutsumi S. Neckers L, et al. Chem Biol. 2007 Nov;14(11):1204-6. doi: 10.1016/j.chembiol.2007.11.002. Chem Biol. 2007. PMID: 18022558

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