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Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.
Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T. Nagata T, et al. Among authors: arimura n. Nat Biotechnol. 2021 Dec;39(12):1529-1536. doi: 10.1038/s41587-021-00972-x. Epub 2021 Aug 12. Nat Biotechnol. 2021. PMID: 34385691
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation.
Miyakawa S, Sakuma H, Warude D, Asanuma S, Arimura N, Yoshihara T, Tavares D, Hata A, Ida K, Hori Y, Okuzono Y, Yamamoto S, Iida K, Shimizu H, Kondo S, Sato S. Miyakawa S, et al. Among authors: arimura n. Front Neurosci. 2020 Dec 15;14:586107. doi: 10.3389/fnins.2020.586107. eCollection 2020. Front Neurosci. 2020. PMID: 33384578 Free PMC article.
Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration.
Arimura N, Maeda C, Aoyama K, Yamaguchi N, Sugiura A, Takahashi Y, Maeda R, Ando T, Kamata M, Matsui H, Tanaka M. Arimura N, et al. PLoS One. 2024 Nov 21;19(11):e0312090. doi: 10.1371/journal.pone.0312090. eCollection 2024. PLoS One. 2024. PMID: 39570850 Free PMC article.
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.
Rikimaru K, Wakabayashi T, Abe H, Imoto H, Maekawa T, Ujikawa O, Murase K, Matsuo T, Matsumoto M, Nomura C, Tsuge H, Arimura N, Kawakami K, Sakamoto J, Funami M, Mol CD, Snell GP, Bragstad KA, Sang BC, Dougan DR, Tanaka T, Katayama N, Horiguchi Y, Momose Y. Rikimaru K, et al. Among authors: arimura n. Bioorg Med Chem. 2012 Jan 15;20(2):714-33. doi: 10.1016/j.bmc.2011.12.008. Epub 2011 Dec 13. Bioorg Med Chem. 2012. PMID: 22209730
Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.
Rikimaru K, Wakabayashi T, Abe H, Tawaraishi T, Imoto H, Yonemori J, Hirose H, Murase K, Matsuo T, Matsumoto M, Nomura C, Tsuge H, Arimura N, Kawakami K, Sakamoto J, Funami M, Mol CD, Snell GP, Bragstad KA, Sang BC, Dougan DR, Tanaka T, Katayama N, Horiguchi Y, Momose Y. Rikimaru K, et al. Among authors: arimura n. Bioorg Med Chem. 2012 May 15;20(10):3332-58. doi: 10.1016/j.bmc.2012.03.036. Epub 2012 Mar 23. Bioorg Med Chem. 2012. PMID: 22503460
Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase.
Hattori Y, Aoyama K, Maeda J, Arimura N, Takahashi Y, Sasaki M, Fujinaga M, Seki C, Nagai Y, Kawamura K, Yamasaki T, Zhang MR, Higuchi M, Koike T. Hattori Y, et al. Among authors: arimura n. J Med Chem. 2019 Mar 14;62(5):2362-2375. doi: 10.1021/acs.jmedchem.8b01576. Epub 2019 Feb 26. J Med Chem. 2019. PMID: 30753069
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety.
Ikeda S, Sugiyama H, Tokuhara H, Murakami M, Nakamura M, Oguro Y, Aida J, Morishita N, Sogabe S, Dougan DR, Gay SC, Qin L, Arimura N, Takahashi Y, Sasaki M, Kamada Y, Aoyama K, Kimoto K, Kamata M. Ikeda S, et al. Among authors: arimura n. J Med Chem. 2021 Aug 12;64(15):11014-11044. doi: 10.1021/acs.jmedchem.1c00432. Epub 2021 Jul 30. J Med Chem. 2021. PMID: 34328319
89 results