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Combinatorial transcription factor profiles predict mature and functional human islet α and β cells.
Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SC, MacDonald PE, Levy SE, Powers AC, Brissova M. Shrestha S, et al. Among authors: cartailler jp. JCI Insight. 2021 Sep 22;6(18):e151621. doi: 10.1172/jci.insight.151621. JCI Insight. 2021. PMID: 34428183 Free PMC article.
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress.
Shrestha S, Erikson G, Lyon J, Spigelman AF, Bautista A, Manning Fox JE, Dos Santos C, Shokhirev M, Cartailler JP, Hetzer MW, MacDonald PE, Arrojo E Drigo R. Shrestha S, et al. Among authors: cartailler jp. Sci Adv. 2022 Oct 7;8(40):eabo3932. doi: 10.1126/sciadv.abo3932. Epub 2022 Oct 5. Sci Adv. 2022. PMID: 36197983 Free PMC article.
Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss.
Richardson TM, Saunders DC, Haliyur R, Shrestha S, Cartailler JP, Reinert RB, Petronglo J, Bottino R, Aramandla R, Bradley AM, Jenkins R, Phillips S, Kang H; Human Pancreas Analysis Program; Caicedo A, Powers AC, Brissova M. Richardson TM, et al. Among authors: cartailler jp. Am J Physiol Endocrinol Metab. 2023 Mar 1;324(3):E251-E267. doi: 10.1152/ajpendo.00246.2022. Epub 2023 Jan 25. Am J Physiol Endocrinol Metab. 2023. PMID: 36696598 Free PMC article.
The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults.
Nakhe AY, Dadi PK, Kim J, Dickerson MT, Behera S, Dobson JR, Shrestha S, Cartailler JP, Sampson L, Magnuson MA, Jacobson DA. Nakhe AY, et al. Among authors: cartailler jp. bioRxiv [Preprint]. 2024 Feb 27:2023.06.20.545631. doi: 10.1101/2023.06.20.545631. bioRxiv. 2024. Update in: Elife. 2024 May 03;12:RP89967. doi: 10.7554/eLife.89967 PMID: 37546831 Free PMC article. Updated. Preprint.
43 results