Ligase 3-mediated end-joining maintains genome stability of human embryonic stem cells.
Kohutova A, Raška J, Kruta M, Seneklova M, Barta T, Fojtik P, Jurakova T, Walter CA, Hampl A, Dvorak P, Rotrekl V.
Kohutova A, et al. Among authors: raska j.
FASEB J. 2019 Jun;33(6):6778-6788. doi: 10.1096/fj.201801877RR. Epub 2019 Feb 26.
FASEB J. 2019.
PMID: 30807703
DSBs in hESCs are also repaired via homologous recombination (HR); however, DSB overload, together with massive end protection by 53BP1, triggers competition between error-free HR and mutagenic nonhomologous EJ.-Kohutova, A., Raska, J., Kruta, M., Seneklova, M., Bar …
DSBs in hESCs are also repaired via homologous recombination (HR); however, DSB overload, together with massive end protection by 53BP1, tri …