Hurdle JG - Search Results

1

Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing.

Marreddy RKR, Olaitan AO, May JN, Dong M, Hurdle JG. Marreddy RKR, et al. Among authors: hurdle jg. Microbiol Spectr. 2021 Oct 31;9(2):e0044821. doi: 10.1128/Spectrum.00448-21. Epub 2021 Sep 1. Microbiol Spectr. 2021. PMID: 34468187 Free PMC article.

2

Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile.

Alam MZ, Wu X, Mascio C, Chesnel L, Hurdle JG. Alam MZ, et al. Among authors: hurdle jg. Antimicrob Agents Chemother. 2015 Sep;59(9):5165-70. doi: 10.1128/AAC.01087-15. Epub 2015 Jun 8. Antimicrob Agents Chemother. 2015. PMID: 26055381 Free PMC article.

3

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Tao L, et al. Among authors: hurdle jg. Nature. 2016 Oct 20;538(7625):350-355. doi: 10.1038/nature19799. Epub 2016 Sep 28. Nature. 2016. PMID: 27680706 Free PMC article.

4

New β-lactam - Tetramic acid hybrids show promising antibacterial activities.

Cherian PT, Cheramie MN, Marreddy RKR, Fernando DM, Hurdle JG, Lee RE. Cherian PT, et al. Among authors: hurdle jg. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3105-3112. doi: 10.1016/j.bmcl.2018.07.018. Epub 2018 Jul 17. Bioorg Med Chem Lett. 2018. PMID: 30097368

5

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection.

Marreddy RKR, Wu X, Sapkota M, Prior AM, Jones JA, Sun D, Hevener KE, Hurdle JG. Marreddy RKR, et al. Among authors: hurdle jg. ACS Infect Dis. 2019 Feb 8;5(2):208-217. doi: 10.1021/acsinfecdis.8b00205. Epub 2018 Dec 13. ACS Infect Dis. 2019. PMID: 30501172 Free PMC article.

6

Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity.

Jones JA, Prior AM, Marreddy RKR, Wahrmund RD, Hurdle JG, Sun D, Hevener KE. Jones JA, et al. Among authors: hurdle jg. ACS Chem Biol. 2019 Jul 19;14(7):1528-1535. doi: 10.1021/acschembio.9b00293. Epub 2019 Jun 26. ACS Chem Biol. 2019. PMID: 31184849 Free PMC article.

7

The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

Sapkota M, Marreddy RKR, Wu X, Kumar M, Hurdle JG. Sapkota M, et al. Among authors: hurdle jg. Anaerobe. 2020 Feb;61:102129. doi: 10.1016/j.anaerobe.2019.102129. Epub 2019 Nov 21. Anaerobe. 2020. PMID: 31760080 Free PMC article.

8

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates.

Shen WJ, Deshpande A, Hevener KE, Endres BT, Garey KW, Palmer KL, Hurdle JG. Shen WJ, et al. Among authors: hurdle jg. J Antimicrob Chemother. 2020 Apr 1;75(4):859-867. doi: 10.1093/jac/dkz513. J Antimicrob Chemother. 2020. PMID: 31873741 Free PMC article.

9

Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases.

Deshpande A, Wu X, Huo W, Palmer KL, Hurdle JG. Deshpande A, et al. Among authors: hurdle jg. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00415-20. doi: 10.1128/AAC.00415-20. Print 2020 Jul 22. Antimicrob Agents Chemother. 2020. PMID: 32457109 Free PMC article.

10

The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests.

Wu X, Shen WJ, Deshpande A, Olaitan AO, Palmer KL, Garey KW, Hurdle JG. Wu X, et al. Among authors: hurdle jg. J Clin Microbiol. 2021 Aug 18;59(9):e0058521. doi: 10.1128/JCM.00585-21. Epub 2021 Aug 18. J Clin Microbiol. 2021. PMID: 34132582 Free PMC article.

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