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Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19.
McIntosh JA, Benkovics T, Silverman SM, Huffman MA, Kong J, Maligres PE, Itoh T, Yang H, Verma D, Pan W, Ho HI, Vroom J, Knight AM, Hurtak JA, Klapars A, Fryszkowska A, Morris WJ, Strotman NA, Murphy GS, Maloney KM, Fier PS. McIntosh JA, et al. Among authors: klapars a. ACS Cent Sci. 2021 Dec 22;7(12):1980-1985. doi: 10.1021/acscentsci.1c00608. Epub 2021 Oct 29. ACS Cent Sci. 2021. PMID: 34963891 Free PMC article.
Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods.
Klapars A, Chung JYL, Limanto J, Calabria R, Campeau LC, Campos KR, Chen W, Dalby SM, Davis TA, DiRocco DA, Hyde AM, Kassim AM, Larsen MU, Liu G, Maligres PE, Moment A, Peng F, Ruck RT, Shevlin M, Simmons BL, Song ZJ, Tan L, Wright TJ, Zultanski SL. Klapars A, et al. Chem Sci. 2021 May 19;12(26):9031-9036. doi: 10.1039/d1sc01978c. eCollection 2021 Jul 7. Chem Sci. 2021. PMID: 34276931 Free PMC article.
Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances.
Haidar Ahmad IA , Chen W , Halsey HM , Klapars A , Limanto J , Pirrone GF , Nowak T , Bennett R , Hartman R , Makarov AA , Mangion I , Regalado EL . Haidar Ahmad IA , et al. Among authors: klapars a. Analyst. 2019 Apr 23;144(9):2872-2880. doi: 10.1039/c8an02499e. Analyst. 2019. PMID: 30830135
Enantioselective synthesis of an HCV NS5a antagonist.
Mangion IK, Chen CY, Li H, Maligres P, Chen Y, Christensen M, Cohen R, Jeon I, Klapars A, Krska S, Nguyen H, Reamer RA, Sherry BD, Zavialov I. Mangion IK, et al. Among authors: klapars a. Org Lett. 2014 May 2;16(9):2310-3. doi: 10.1021/ol500971c. Epub 2014 Apr 11. Org Lett. 2014. PMID: 24724971
A multifunctional catalyst that stereoselectively assembles prodrugs.
DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW. DiRocco DA, et al. Among authors: klapars a. Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936. Science. 2017. PMID: 28450641
35 results