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An acetylation site in the middle domain of Hsp90 regulates chaperone function.
Scroggins BT, Robzyk K, Wang D, Marcu MG, Tsutsumi S, Beebe K, Cotter RJ, Felts S, Toft D, Karnitz L, Rosen N, Neckers L. Scroggins BT, et al. Among authors: neckers l. Mol Cell. 2007 Jan 12;25(1):151-9. doi: 10.1016/j.molcel.2006.12.008. Mol Cell. 2007. PMID: 17218278 Free PMC article.
A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity.
Ansar S, Burlison JA, Hadden MK, Yu XM, Desino KE, Bean J, Neckers L, Audus KL, Michaelis ML, Blagg BS. Ansar S, et al. Among authors: neckers l. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1984-90. doi: 10.1016/j.bmcl.2007.01.017. Epub 2007 Jan 17. Bioorg Med Chem Lett. 2007. PMID: 17276679
Update on Hsp90 inhibitors in clinical trial.
Kim YS, Alarcon SV, Lee S, Lee MJ, Giaccone G, Neckers L, Trepel JB. Kim YS, et al. Among authors: neckers l. Curr Top Med Chem. 2009;9(15):1479-92. doi: 10.2174/156802609789895728. Curr Top Med Chem. 2009. PMID: 19860730 Free PMC article. Review.
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.
Mollapour M, Tsutsumi S, Donnelly AC, Beebe K, Tokita MJ, Lee MJ, Lee S, Morra G, Bourboulia D, Scroggins BT, Colombo G, Blagg BS, Panaretou B, Stetler-Stevenson WG, Trepel JB, Piper PW, Prodromou C, Pearl LH, Neckers L. Mollapour M, et al. Among authors: neckers l. Mol Cell. 2010 Feb 12;37(3):333-43. doi: 10.1016/j.molcel.2010.01.005. Mol Cell. 2010. PMID: 20159553 Free PMC article.
A systematic protocol for the characterization of Hsp90 modulators.
Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS. Matts RL, et al. Among authors: neckers l. Bioorg Med Chem. 2011 Jan 1;19(1):684-92. doi: 10.1016/j.bmc.2010.10.029. Epub 2010 Oct 19. Bioorg Med Chem. 2011. PMID: 21129982 Free PMC article.
407 results