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Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.
Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keleş S, Moskowitz IP, Keller MP, Attie AD. Simonett SP, et al. Among authors: keles s. J Clin Invest. 2021 Nov 1;131(21):e144833. doi: 10.1172/JCI144833. J Clin Invest. 2021. PMID: 34491912 Free PMC article.
atSNP: transcription factor binding affinity testing for regulatory SNP detection.
Zuo C, Shin S, Keleş S. Zuo C, et al. Among authors: keles s. Bioinformatics. 2015 Oct 15;31(20):3353-5. doi: 10.1093/bioinformatics/btv328. Epub 2015 Jun 18. Bioinformatics. 2015. PMID: 26092860 Free PMC article.
RESULTS: We describe A: ffinity T: esting for regulatory SNP: s (atSNP), a computationally efficient R package for identifying rSNPs in silico. atSNP implements an importance sampling algorithm coupled with a first-order Markov model for the background nucleotide sequences …
RESULTS: We describe A: ffinity T: esting for regulatory SNP: s (atSNP), a computationally efficient R package for identifying rSNPs …
Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks.
Jung MM, Shen S, Botten GA, Olender T, Katsumura KR, Johnson KD, Soukup AA, Liu P, Zhang Q, Jensvold ZD, Lewis PW, Beagrie RA, Low JK, Yang L, Mackay JP, Godley LA, Brand M, Xu J, Keles S, Bresnick EH. Jung MM, et al. Among authors: keles s. J Clin Invest. 2023 Apr 3;133(7):e162685. doi: 10.1172/JCI162685. J Clin Invest. 2023. PMID: 36809258 Free PMC article.
396 results