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Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.
Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keleş S, Moskowitz IP, Keller MP, Attie AD. Simonett SP, et al. Among authors: moskowitz ip. J Clin Invest. 2021 Nov 1;131(21):e144833. doi: 10.1172/JCI144833. J Clin Invest. 2021. PMID: 34491912 Free PMC article.
TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IP. Arnolds DE, et al. Among authors: moskowitz ip. J Clin Invest. 2012 Jul;122(7):2509-18. doi: 10.1172/JCI62617. Epub 2012 Jun 25. J Clin Invest. 2012. PMID: 22728936 Free PMC article.
Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP. Yang XH, et al. Among authors: moskowitz ip. Elife. 2017 Dec 27;6:e31683. doi: 10.7554/eLife.31683. Elife. 2017. PMID: 29280435 Free PMC article.
Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IP. Rowton M, et al. Among authors: moskowitz ip. Dev Cell. 2022 Sep 26;57(18):2181-2203.e9. doi: 10.1016/j.devcel.2022.08.009. Epub 2022 Sep 14. Dev Cell. 2022. PMID: 36108627 Free PMC article.
A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP. Broman MT, et al. Among authors: moskowitz ip. Circulation. 2024 Apr 9;149(15):1205-1230. doi: 10.1161/CIRCULATIONAHA.123.066804. Epub 2024 Jan 8. Circulation. 2024. PMID: 38189150
Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.
Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Arulsamy K, Lu F, Keating EM, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Hill LD, Kyoung Song M, Trembley MA, Wang P, Gianeselli M, Prondzynski M, Bortolin RH, Bezzerides VJ, Chen K, Seidman JG, Seidman CE, Moskowitz IP, Pu WT. Sweat ME, et al. Among authors: moskowitz ip. Nat Cardiovasc Res. 2023 Oct;2(10):881-898. doi: 10.1038/s44161-023-00334-7. Epub 2023 Oct 12. Nat Cardiovasc Res. 2023. PMID: 38344303 Free PMC article.
A common genetic variant within SCN10A modulates cardiac SCN5A expression.
van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP. van den Boogaard M, et al. Among authors: moskowitz ip. J Clin Invest. 2014 Apr;124(4):1844-52. doi: 10.1172/JCI73140. Epub 2014 Mar 18. J Clin Invest. 2014. PMID: 24642470 Free PMC article.
87 results