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Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.
Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keleş S, Moskowitz IP, Keller MP, Attie AD. Simonett SP, et al. Among authors: stein r. J Clin Invest. 2021 Nov 1;131(21):e144833. doi: 10.1172/JCI144833. J Clin Invest. 2021. PMID: 34491912 Free PMC article.
The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.
Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT Jr, Powers AC, Gu G, Stein R. Conrad E, et al. Among authors: stein r. Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E91-E102. doi: 10.1152/ajpendo.00285.2015. Epub 2015 Nov 10. Am J Physiol Endocrinol Metab. 2016. PMID: 26554594 Free PMC article.
Impact of Pdx1-associated chromatin modifiers on islet β-cells.
Spaeth JM, Walker EM, Stein R. Spaeth JM, et al. Among authors: stein r. Diabetes Obes Metab. 2016 Sep;18 Suppl 1(Suppl 1):123-7. doi: 10.1111/dom.12730. Diabetes Obes Metab. 2016. PMID: 27615141 Free PMC article. Review.
Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.
Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC. Dean ED, et al. Among authors: stein r. Cell Metab. 2017 Jun 6;25(6):1362-1373.e5. doi: 10.1016/j.cmet.2017.05.011. Cell Metab. 2017. PMID: 28591638 Free PMC article.
Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks.
Haliyur R, Tong X, Sanyoura M, Shrestha S, Lindner J, Saunders DC, Aramandla R, Poffenberger G, Redick SD, Bottino R, Prasad N, Levy SE, Blind RD, Harlan DM, Philipson LH, Stein RW, Brissova M, Powers AC. Haliyur R, et al. Among authors: stein rw. J Clin Invest. 2019 Jan 2;129(1):246-251. doi: 10.1172/JCI121994. Epub 2018 Dec 3. J Clin Invest. 2019. PMID: 30507613 Free PMC article.
3,122 results