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A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors.
Di Giulio S, Colicchia V, Pastorino F, Pedretti F, Fabretti F, Nicolis di Robilant V, Ramponi V, Scafetta G, Moretti M, Licursi V, Belardinilli F, Peruzzi G, Infante P, Goffredo BM, Coppa A, Canettieri G, Bartolazzi A, Ponzoni M, Giannini G, Petroni M. Di Giulio S, et al. Among authors: goffredo bm. Oncogene. 2021 Oct;40(43):6143-6152. doi: 10.1038/s41388-021-02003-0. Epub 2021 Sep 10. Oncogene. 2021. PMID: 34508175 Free PMC article.
Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.
Di Magno L, Manni S, Di Pastena F, Coni S, Macone A, Cairoli S, Sambucci M, Infante P, Moretti M, Petroni M, Nicoletti C, Capalbo C, De Smaele E, Di Marcotullio L, Giannini G, Battistini L, Goffredo BM, Iorio E, Agostinelli E, Maroder M, Canettieri G. Di Magno L, et al. Among authors: goffredo bm. Cell Rep. 2020 Feb 11;30(6):1735-1752.e7. doi: 10.1016/j.celrep.2020.01.024. Cell Rep. 2020. PMID: 32049007 Free article.
GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape.
Caforio M, Sorino C, Caruana I, Weber G, Camera A, Cifaldi L, De Angelis B, Del Bufalo F, Vitale A, Goffredo BM, De Vito R, Fruci D, Quintarelli C, Fanciulli M, Locatelli F, Folgiero V. Caforio M, et al. Among authors: goffredo bm. J Immunother Cancer. 2021 Mar;9(3):e001502. doi: 10.1136/jitc-2020-001502. J Immunother Cancer. 2021. PMID: 33737337 Free PMC article.
79 results