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Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia.
Thiebaut AM, Buendia I, Ginet V, Lemarchand E, Boudjadja MB, Hommet Y, Lebouvier L, Lechevallier C, Maillasson M, Hedou E, Déglon N, Oury F, Rubio M, Montaner J, Puyal J, Vivien D, Roussel BD. Thiebaut AM, et al. Among authors: lechevallier c. Autophagy. 2022 Jun;18(6):1297-1317. doi: 10.1080/15548627.2021.1973339. Epub 2021 Sep 14. Autophagy. 2022. PMID: 34520334 Free PMC article.