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Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets.
Popadynec M, Baradaran-Heravi A, Alford B, Cameron SA, Clinch K, Mason JM, Rendle PM, Zubkova OV, Gan Z, Liu H, Rebollo O, Whitfield DM, Yan F, Roberge M, Powell DA. Popadynec M, et al. Among authors: baradaran heravi a. ACS Med Chem Lett. 2021 Aug 9;12(9):1486-1492. doi: 10.1021/acsmedchemlett.1c00349. eCollection 2021 Sep 9. ACS Med Chem Lett. 2021. PMID: 34531957 Free PMC article.
Novel small molecules potentiate premature termination codon readthrough by aminoglycosides.
Baradaran-Heravi A, Balgi AD, Zimmerman C, Choi K, Shidmoossavee FS, Tan JS, Bergeaud C, Krause A, Flibotte S, Shimizu Y, Anderson HJ, Mouly V, Jan E, Pfeifer T, Jaquith JB, Roberge M. Baradaran-Heravi A, et al. Nucleic Acids Res. 2016 Aug 19;44(14):6583-98. doi: 10.1093/nar/gkw638. Epub 2016 Jul 12. Nucleic Acids Res. 2016. PMID: 27407112 Free PMC article.
Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity.
Baradaran-Heravi A, Niesser J, Balgi AD, Choi K, Zimmerman C, South AP, Anderson HJ, Strynadka NC, Bally MB, Roberge M. Baradaran-Heravi A, et al. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3479-3484. doi: 10.1073/pnas.1620982114. Epub 2017 Mar 13. Proc Natl Acad Sci U S A. 2017. Retraction in: Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11885. doi: 10.1073/pnas.1818172115 PMID: 28289221 Free PMC article. Retracted.
Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency.
Frew J, Baradaran-Heravi A, Balgi AD, Wu X, Yan TD, Arns S, Shidmoossavee FS, Tan J, Jaquith JB, Jansen-West KR, Lynn FC, Gao FB, Petrucelli L, Feldman HH, Mackenzie IR, Roberge M, Nygaard HB. Frew J, et al. Among authors: baradaran heravi a. Mol Neurodegener. 2020 Mar 16;15(1):21. doi: 10.1186/s13024-020-00369-5. Mol Neurodegener. 2020. PMID: 32178712 Free PMC article.
31 results