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Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice.
Moreira LKDS, Silva RR, da Silva DM, Mendes MAS, de Brito AF, de Carvalho FS, Sanz G, Rodrigues MF, da Silva ACG, Thomaz DV, de Oliveira V, Vaz BG, Lião LM, Valadares MC, Gil ES, Costa EA, Noël F, Menegatti R. Moreira LKDS, et al. Among authors: silva rr. Behav Brain Res. 2022 Jan 24;417:113582. doi: 10.1016/j.bbr.2021.113582. Epub 2021 Sep 15. Behav Brain Res. 2022. PMID: 34536431
A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.
Brito AF, Braga PCCS, Moreira LKS, Silva DM, Silva DPB, Sanz G, Vaz BG, de Carvalho FS, Lião LM, Silva RR, Noël F, Neri HFS, Ghedini PC, de Carvalho MF, de S Gil E, Costa EA, Menegatti R. Brito AF, et al. Among authors: silva rr, silva dm, silva dpb. Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):255-269. doi: 10.1007/s00210-017-1451-7. Epub 2017 Dec 19. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29260264
Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.
Silva RR, Parreiras-E-Silva LT, Pompeu TET, Duarte DA, Fraga CAM, Barreiro EJ, Menegatti R, Costa-Neto CM, Noël F. Silva RR, et al. Front Pharmacol. 2019 Jun 4;10:628. doi: 10.3389/fphar.2019.00628. eCollection 2019. Front Pharmacol. 2019. PMID: 31214037 Free PMC article.
Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases.
da Silva Cunha TT, Silva RR, Rodrigues DA, de Sena Murteira Pinheiro P, Kronenberger T, Sant'Anna CMR, Noël F, Fraga CAM. da Silva Cunha TT, et al. Among authors: silva rr. Biomolecules. 2022 Aug 12;12(8):1112. doi: 10.3390/biom12081112. Biomolecules. 2022. PMID: 36009006 Free PMC article.
L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke.
Carvalho GA, Chiareli RA, Marques BL, Parreira RC, de Souza Gil E, de Carvalho FS, da Rocha ALB, Silva RR, Noël F, Vaz BG, Lião LM, Ahmad S, Verli H, Menegatti R, Pinto MCX. Carvalho GA, et al. Among authors: silva rr. Pharmacol Rep. 2023 Apr;75(2):276-292. doi: 10.1007/s43440-023-00451-x. Epub 2023 Jan 31. Pharmacol Rep. 2023. PMID: 36719635
599 results