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Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.
Schäfer A, Martinez DR, Won JJ, Moreira FR, Brown AJ, Gully KL, Kalla R, Chun K, Du Pont V, Babusis D, Tang J, Murakami E, Subramanian R, Barrett KT, Bleier BJ, Bannister R, Feng JY, Bilello JP, Cihlar T, Mackman RL, Montgomery SA, Baric RS, Sheahan TP. Schäfer A, et al. Among authors: subramanian r. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111. doi: 10.1101/2021.09.13.460111. bioRxiv. 2021. Update in: Sci Transl Med. 2022 May 4;14(643):eabm3410. doi: 10.1126/scitranslmed.abm3410 PMID: 34545367 Free PMC article. Updated. Preprint.
Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
Siegel DS, Hui HC, Pitts J, Vermillion MS, Ishida K, Rautiola D, Keeney M, Irshad H, Zhang L, Chun K, Chin G, Goyal B, Doerffler E, Yang H, Clarke MO, Palmiotti C, Vijjapurapu A, Riola NC, Stray K, Murakami E, Ma B, Wang T, Zhao X, Xu Y, Lee G, Marchand B, Seung M, Nayak A, Tomkinson A, Kadrichu N, Ellis S, Barauskas O, Feng JY, Perry JK, Perron M, Bilello JP, Kuehl PJ, Subramanian R, Cihlar T, Mackman RL. Siegel DS, et al. Among authors: subramanian r. J Med Chem. 2024 Aug 8;67(15):12945-12968. doi: 10.1021/acs.jmedchem.4c00899. Epub 2024 Jul 17. J Med Chem. 2024. PMID: 39018526
Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein.
Kornyeyev D, Song Z, Eng S, Soulette C, Ramirez R, Tang J, Yue Q, Subramanian R, Zaboli S, Moon C, Tam J, Brodbeck J, Aggarwal A, Diehl L, Fletcher SP, Hyrina A, Holdorf MM, Burdette D. Kornyeyev D, et al. Among authors: subramanian r. Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0042024. doi: 10.1128/aac.00420-24. Epub 2024 May 23. Antimicrob Agents Chemother. 2024. PMID: 38780261 Free PMC article.
Pharmacokinetics, Disposition, and Biotransformation of [14C]Lenacapavir, a Novel, First-in-Class, Selective Inhibitor of HIV-1 Capsid Function, in Healthy Participants Following a Single Intravenous Infusion.
Weber E, Subramanian R, Rowe W, Graupe M, Ling J, Shen G, Begley R, Sager J, Wolckenhauer S, Rhee M, Palaparthy R, Singh R. Weber E, et al. Among authors: subramanian r. Clin Pharmacokinet. 2024 Feb;63(2):241-253. doi: 10.1007/s40262-023-01328-1. Epub 2024 Jan 18. Clin Pharmacokinet. 2024. PMID: 38236562
Formulation of Asiatic acid-loaded polymeric chitosan-based hydrogel for effective MRSA infection control and enhanced wound healing in zebrafish models.
Kandaswamy K, Panda SP, Shaik MR, Hussain SA, Deepak P, Thiyagarajulu N, Jain D, Antonyraj APM, Subramanian R, Guru A, Arockiaraj J. Kandaswamy K, et al. Among authors: subramanian r. Int J Biol Macromol. 2024 Nov 12:137425. doi: 10.1016/j.ijbiomac.2024.137425. Online ahead of print. Int J Biol Macromol. 2024. PMID: 39542332
757 results