Somervaille TCP - Search Results

1

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

Simeoni F, Romero-Camarero I, Camera F, Amaral FMR, Sinclair OJ, Papachristou EK, Spencer GJ, Lie-A-Ling M, Lacaud G, Wiseman DH, Carroll JS, Somervaille TCP. Simeoni F, et al. Among authors: somervaille tcp. Cell Rep. 2021 Sep 21;36(12):109725. doi: 10.1016/j.celrep.2021.109725. Cell Rep. 2021. PMID: 34551306 Free PMC article.

2

MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis.

Mascarenhas J, Kremyanskaya M, Patriarca A, Palandri F, Devos T, Passamonti F, Rampal RK, Mead AJ, Hobbs G, Scandura JM, Talpaz M, Granacher N, Somervaille TCP, Hoffman R, Wondergem MJ, Salama ME, Colak G, Cui J, Kiladjian JJ, Vannucchi AM, Verstovsek S, Curto-García N, Harrison C, Gupta V. Mascarenhas J, et al. Among authors: somervaille tcp. J Clin Oncol. 2023 Nov 10;41(32):4993-5004. doi: 10.1200/JCO.22.01972. Epub 2023 Mar 7. J Clin Oncol. 2023. PMID: 36881782 Free PMC article. Clinical Trial.

3

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.

Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM, Chang HY, Shurtleff SA, Downing JR, Cleary ML. Somervaille TC, et al. Cell Stem Cell. 2009 Feb 6;4(2):129-40. doi: 10.1016/j.stem.2008.11.015. Cell Stem Cell. 2009. PMID: 19200802 Free PMC article.

4

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

Harris WJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, Li Y, Ciceri F, Blaser JG, Greystoke BF, Jordan AM, Miller CJ, Ogilvie DJ, Somervaille TC. Harris WJ, et al. Cancer Cell. 2012 Apr 17;21(4):473-87. doi: 10.1016/j.ccr.2012.03.014. Epub 2012 Mar 29. Cancer Cell. 2012. PMID: 22464800 Free article.

5

TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells.

Lynch JT, Somerville TD, Spencer GJ, Huang X, Somervaille TC. Lynch JT, et al. Cell Death Dis. 2013 Apr 4;4(4):e573. doi: 10.1038/cddis.2013.107. Cell Death Dis. 2013. PMID: 23559008 Free PMC article.

6

The variety of leukemic stem cells in myeloid malignancy.

Wiseman DH, Greystoke BF, Somervaille TC. Wiseman DH, et al. Oncogene. 2014 Jun 12;33(24):3091-8. doi: 10.1038/onc.2013.269. Epub 2013 Jul 8. Oncogene. 2014. PMID: 23831573 Review.

7

CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1.

Lynch JT, Cockerill MJ, Hitchin JR, Wiseman DH, Somervaille TC. Lynch JT, et al. Anal Biochem. 2013 Nov 1;442(1):104-6. doi: 10.1016/j.ab.2013.07.032. Epub 2013 Jul 31. Anal Biochem. 2013. PMID: 23911524

8

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.

Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC. Huang X, et al. Leukemia. 2014 May;28(5):1081-91. doi: 10.1038/leu.2013.316. Epub 2013 Oct 29. Leukemia. 2014. PMID: 24166297 Free PMC article.

9

Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.

Wiseman DH, Small HF, Wilks DP, Waddell ID, Dennis MW, Ogilvie DJ, Somervaille TC. Wiseman DH, et al. Br J Haematol. 2014 Jul;166(1):145-8. doi: 10.1111/bjh.12826. Epub 2014 Mar 10. Br J Haematol. 2014. PMID: 24606602 Free article. No abstract available.

10

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.

Jude JG, Spencer GJ, Huang X, Somerville TDD, Jones DR, Divecha N, Somervaille TCP. Jude JG, et al. Among authors: somervaille tcp. Oncogene. 2015 Mar 5;34(10):1253-1262. doi: 10.1038/onc.2014.77. Epub 2014 Mar 31. Oncogene. 2015. PMID: 24681948 Free PMC article.

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