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Page 1
A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.
Jermusyk A, Zhong J, Connelly KE, Gordon N, Perera S, Abdolalizadeh E, Zhang T, O'Brien A, Hoskins JW, Collins I, Eiser D, Yuan C; PanScan Consortium; PanC4 Consortium; Risch HA, Jacobs EJ, Li D, Du M, Stolzenberg-Solomon RZ, Klein AP, Smith JP, Wolpin BM, Chanock SJ, Shi J, Petersen GM, Westlake CJ, Amundadottir LT. Jermusyk A, et al. Among authors: eiser d. Am J Hum Genet. 2021 Oct 7;108(10):1852-1865. doi: 10.1016/j.ajhg.2021.09.002. Epub 2021 Sep 23. Am J Hum Genet. 2021. PMID: 34559995 Free PMC article.
Allelic effects on KLHL17 expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33.
Connelly KE, Hullin K, Abdolalizadeh E, Zhong J, Eiser D, O'Brien A, Collins I, Sudipto Das, Duncan G; Pancreatic Cancer Cohort Consortium; Pancreatic Cancer Case-Control Consortium; Chanock SJ, Stolzenberg-Solomon RZ, Klein AP, Wolpin BM, Hoskins JW, Andresson T, Smith JP, Amundadottir LT. Connelly KE, et al. Among authors: eiser d. medRxiv [Preprint]. 2024 Sep 16:2024.09.16.24313748. doi: 10.1101/2024.09.16.24313748. medRxiv. 2024. PMID: 39371158 Free PMC article. Preprint.
Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma.
Zhong J, O'Brien A, Patel M, Eiser D, Mobaraki M, Collins I, Wang L, Guo K, TruongVo T, Jermusyk A, O'Neill M, Dill CD, Wells AD, Leonard ME, Pippin JA, Grant SFA, Zhang T, Andresson T, Connelly KE, Shi J, Arda HE, Hoskins JW, Amundadottir LT. Zhong J, et al. Among authors: eiser d. medRxiv [Preprint]. 2024 Sep 24:2024.09.22.24314165. doi: 10.1101/2024.09.22.24314165. medRxiv. 2024. PMID: 39371173 Free PMC article. Preprint.
Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo.
Geretz A, Ehrenberg PK, Clifford RJ, Laliberté A, Prelli Bozzo C, Eiser D, Kundu G, Yum LK, Apps R, Creegan M, Gunady M, Shangguan S, Sanders-Buell E, Sacdalan C, Phanuphak N, Tovanabutra S, Russell RM, Bibollet-Ruche F, Robb ML, Michael NL, Ake JA, Vasan S, Hsu DC, Hahn BH, Kirchhoff F, Thomas R. Geretz A, et al. Among authors: eiser d. Sci Transl Med. 2023 Aug 2;15(707):eadg0873. doi: 10.1126/scitranslmed.adg0873. Epub 2023 Aug 2. Sci Transl Med. 2023. PMID: 37531416