Ory DS - Search Results

1

IP₃R-driven increases in mitochondrial Ca²⁺ promote neuronal death in NPC disease.

Tiscione SA, Casas M, Horvath JD, Lam V, Hino K, Ory DS, Santana LF, Simó S, Dixon RE, Dickson EJ. Tiscione SA, et al. Among authors: ory ds. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2110629118. doi: 10.1073/pnas.2110629118. Proc Natl Acad Sci U S A. 2021. PMID: 34580197 Free PMC article.

2

Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.

Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Langmade SJ, et al. Among authors: ory ds. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13807-12. doi: 10.1073/pnas.0606218103. Epub 2006 Aug 29. Proc Natl Acad Sci U S A. 2006. PMID: 16940355 Free PMC article.

3

Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P₂ That Regulates Neuronal Excitability.

Vivas O, Tiscione SA, Dixon RE, Ory DS, Dickson EJ. Vivas O, et al. Among authors: ory ds. Cell Rep. 2019 May 28;27(9):2636-2648.e4. doi: 10.1016/j.celrep.2019.04.099. Cell Rep. 2019. PMID: 31141688 Free PMC article.

4

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.

Tiscione SA, Vivas O, Ginsburg KS, Bers DM, Ory DS, Santana LF, Dixon RE, Dickson EJ. Tiscione SA, et al. Among authors: ory ds. J Cell Biol. 2019 Dec 2;218(12):4141-4156. doi: 10.1083/jcb.201903018. Epub 2019 Oct 10. J Cell Biol. 2019. PMID: 31601621 Free PMC article.

5

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.

Xiao X, Kim Y, Romartinez-Alonso B, Sirvydis K, Ory DS, Schwabe JWR, Jung ME, Tontonoz P. Xiao X, et al. Among authors: ory ds. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2024149118. doi: 10.1073/pnas.2024149118. Proc Natl Acad Sci U S A. 2021. PMID: 33376205 Free PMC article.

6

NPC1 regulates the distribution of phosphatidylinositol 4-kinases at Golgi and lysosomal membranes.

Kutchukian C, Vivas O, Casas M, Jones JG, Tiscione SA, Simó S, Ory DS, Dixon RE, Dickson EJ. Kutchukian C, et al. Among authors: ory ds. EMBO J. 2021 Jul 1;40(13):e105990. doi: 10.15252/embj.2020105990. Epub 2021 May 21. EMBO J. 2021. PMID: 34019311 Free PMC article.

7

Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis.

Millard EE, Srivastava K, Traub LM, Schaffer JE, Ory DS. Millard EE, et al. Among authors: ory ds. J Biol Chem. 2000 Dec 8;275(49):38445-51. doi: 10.1074/jbc.M003180200. J Biol Chem. 2000. PMID: 10964915 Free article.

8

Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function.

Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS. Frolov A, et al. Among authors: ory ds. J Biol Chem. 2001 Dec 7;276(49):46414-21. doi: 10.1074/jbc.M108099200. Epub 2001 Sep 24. J Biol Chem. 2001. PMID: 11571306 Free article.

9

Triglyceride accumulation protects against fatty acid-induced lipotoxicity.

Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, Schaffer JE. Listenberger LL, et al. Among authors: ory ds. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3077-82. doi: 10.1073/pnas.0630588100. Epub 2003 Mar 10. Proc Natl Acad Sci U S A. 2003. PMID: 12629214 Free PMC article.

10

NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.

Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE, Ory DS. Frolov A, et al. Among authors: ory ds. J Biol Chem. 2003 Jul 11;278(28):25517-25. doi: 10.1074/jbc.M302588200. Epub 2003 Apr 28. J Biol Chem. 2003. PMID: 12719428 Free article.

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