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Ikaros deficiency is associated with aggressive BCR-ABL1 B-cell precursor acute lymphoblastic leukemia independent of the lineage and developmental origin.
Simand C, Keime C, Cayé A, Arfeuille C, Passet M, Kim R, Cavé H, Clappier E, Kastner P, Chan S, Heizmann B. Simand C, et al. Among authors: heizmann b. Haematologica. 2022 Jan 1;107(1):316-320. doi: 10.3324/haematol.2021.279125. Haematologica. 2022. PMID: 34587720 Free PMC article. No abstract available.
The Ikaros family in lymphocyte development.
Heizmann B, Kastner P, Chan S. Heizmann B, et al. Curr Opin Immunol. 2018 Apr;51:14-23. doi: 10.1016/j.coi.2017.11.005. Epub 2017 Dec 24. Curr Opin Immunol. 2018. PMID: 29278858 Review.
Large deletions of the 5' region of IKZF1 lead to haploinsufficiency in B-cell precursor acute lymphoblastic leukaemia.
Morel G, Deau MC, Simand C, Caye-Eude A, Arfeuille C, Ittel A, Miguet L, Mauvieux L, Herbrecht R, Paillard C, Strullu M, Cavé H, Chan S, Kastner P, Heizmann B. Morel G, et al. Among authors: heizmann b. Br J Haematol. 2019 Sep;186(5):e155-e159. doi: 10.1111/bjh.15994. Epub 2019 May 30. Br J Haematol. 2019. PMID: 31148164 Free article. No abstract available.
Ikaros Is a Negative Regulator of B1 Cell Development and Function.
Macias-Garcia A, Heizmann B, Sellars M, Marchal P, Dali H, Pasquali JL, Muller S, Kastner P, Chan S. Macias-Garcia A, et al. Among authors: heizmann b. J Biol Chem. 2016 Apr 22;291(17):9073-86. doi: 10.1074/jbc.M115.704239. Epub 2016 Feb 3. J Biol Chem. 2016. PMID: 26841869 Free PMC article.
Ikaros antagonizes DNA binding by STAT5 in pre-B cells.
Heizmann B, Le Gras S, Simand C, Marchal P, Chan S, Kastner P. Heizmann B, et al. PLoS One. 2020 Nov 12;15(11):e0242211. doi: 10.1371/journal.pone.0242211. eCollection 2020. PLoS One. 2020. PMID: 33180866 Free PMC article.
Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL.
Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, Sexton T, Quentin S, Hernandez L, Larcher L, Bergugnat H, Ye T, Karasu N, Caye A, Heizmann B, Duluc I, Chevallier P, Rousselot P, Huguet F, Leguay T, Hunault M, Pflumio F, Freund JN, Lobry C, Lhéritier V, Dombret H, Domon-Dell C, Soulier J, Boissel N, Clappier E. Passet M, et al. Among authors: heizmann b. Blood. 2022 Jun 16;139(24):3505-3518. doi: 10.1182/blood.2021014723. Blood. 2022. PMID: 35316324 Free PMC article.
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