Hu C - Search Results

1

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.

Hu C, Almendros C, Nam KH, Costa AR, Vink JNA, Haagsma AC, Bagde SR, Brouns SJJ, Ke A. Hu C, et al. Nature. 2021 Oct;598(7881):515-520. doi: 10.1038/s41586-021-03951-z. Epub 2021 Sep 29. Nature. 2021. PMID: 34588691 Free PMC article.

2

Real-time observation of CRISPR spacer acquisition by Cas1-Cas2 integrase.

Budhathoki JB, Xiao Y, Schuler G, Hu C, Cheng A, Ding F, Ke A. Budhathoki JB, et al. Among authors: hu c. Nat Struct Mol Biol. 2020 May;27(5):489-499. doi: 10.1038/s41594-020-0415-7. Epub 2020 May 4. Nat Struct Mol Biol. 2020. PMID: 32367067 Free PMC article.

3

Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3.

Hou Z, Hu C, Ke A, Zhang Y. Hou Z, et al. Among authors: hu c. Curr Protoc. 2022 Feb;2(2):e361. doi: 10.1002/cpz1.361. Curr Protoc. 2022. PMID: 35129865 Free PMC article.

4

Structural basis for RNA-guided DNA cleavage by IscB-ωRNA and mechanistic comparison with Cas9.

Schuler G, Hu C, Ke A. Schuler G, et al. Among authors: hu c. Science. 2022 Jun 24;376(6600):1476-1481. doi: 10.1126/science.abq7220. Epub 2022 May 26. Science. 2022. PMID: 35617371 Free PMC article.

5

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.

Hu C, Ni D, Nam KH, Majumdar S, McLean J, Stahlberg H, Terns MP, Ke A. Hu C, et al. Mol Cell. 2022 Aug 4;82(15):2754-2768.e5. doi: 10.1016/j.molcel.2022.06.007. Epub 2022 Jul 13. Mol Cell. 2022. PMID: 35835111 Free PMC article.

6

Reconstitution and biochemical characterization of the RNA-guided helicase-nuclease protein Cas3 from type I-A CRISPR-Cas system.

Hu C, Ke A. Hu C, et al. Methods Enzymol. 2022;673:405-424. doi: 10.1016/bs.mie.2022.03.059. Epub 2022 Apr 27. Methods Enzymol. 2022. PMID: 35965014

7

Craspase is a CRISPR RNA-guided, RNA-activated protease.

Hu C, van Beljouw SPB, Nam KH, Schuler G, Ding F, Cui Y, Rodríguez-Molina A, Haagsma AC, Valk M, Pabst M, Brouns SJJ, Ke A. Hu C, et al. Science. 2022 Sep 16;377(6612):1278-1285. doi: 10.1126/science.add5064. Epub 2022 Aug 25. Science. 2022. PMID: 36007061 Free PMC article.

8

Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications.

Hu C, Myers MT, Zhou X, Hou Z, Lozen ML, Zhang Y, Ke A. Hu C, et al. bioRxiv [Preprint]. 2023 Aug 6:2023.08.05.552134. doi: 10.1101/2023.08.05.552134. bioRxiv. 2023. Update in: Mol Cell. 2024 Feb 1;84(3):463-475.e5. doi: 10.1016/j.molcel.2023.12.034. PMID: 37577534 Free PMC article. Updated. Preprint.

9

Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.

Hu C, Myers MT, Zhou X, Hou Z, Lozen ML, Nam KH, Zhang Y, Ke A. Hu C, et al. Mol Cell. 2024 Feb 1;84(3):463-475.e5. doi: 10.1016/j.molcel.2023.12.034. Epub 2024 Jan 18. Mol Cell. 2024. PMID: 38242128

10

Structure and genome editing of type I-B CRISPR-Cas.

Lu M, Yu C, Zhang Y, Ju W, Ye Z, Hua C, Mao J, Hu C, Yang Z, Xiao Y. Lu M, et al. Among authors: hu c. Nat Commun. 2024 May 15;15(1):4126. doi: 10.1038/s41467-024-48598-2. Nat Commun. 2024. PMID: 38750051 Free PMC article.

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