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Page 1
Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA.
Hirano S, Kappel K, Altae-Tran H, Faure G, Wilkinson ME, Kannan S, Demircioglu FE, Yan R, Shiozaki M, Yu Z, Makarova KS, Koonin EV, Macrae RK, Zhang F. Hirano S, et al. Among authors: demircioglu fe. Nature. 2022 Oct;610(7932):575-581. doi: 10.1038/s41586-022-05324-6. Epub 2022 Oct 12. Nature. 2022. PMID: 36224386 Free PMC article.
RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
Strecker J, Demircioglu FE, Li D, Faure G, Wilkinson ME, Gootenberg JS, Abudayyeh OO, Nishimasu H, Macrae RK, Zhang F. Strecker J, et al. Among authors: demircioglu fe. Science. 2022 Nov 25;378(6622):874-881. doi: 10.1126/science.add7450. Epub 2022 Nov 3. Science. 2022. PMID: 36423276 Free PMC article.
Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy.
Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong PP, Alexopoulou A, Elia G, Clear A, Ledoux A, Hunter J, Perkins N, Gribben JG, Hodivala-Dilke KM. Tavora B, et al. Nature. 2014 Oct 2;514(7520):112-6. doi: 10.1038/nature13541. Epub 2014 Jul 27. Nature. 2014. PMID: 25079333 Free PMC article.
How lamina-associated polypeptide 1 (LAP1) activates Torsin.
Sosa BA, Demircioglu FE, Chen JZ, Ingram J, Ploegh HL, Schwartz TU. Sosa BA, et al. Among authors: demircioglu fe. Elife. 2014 Aug 22;3:e03239. doi: 10.7554/eLife.03239. Elife. 2014. PMID: 25149450 Free PMC article.
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker AM, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Balkwill FR, Sosabowski J, Cutillas PR, Frezza C, Sancho P, Hodivala-Dilke K. Demircioglu F, et al. Nat Commun. 2020 Mar 10;11(1):1290. doi: 10.1038/s41467-020-15104-3. Nat Commun. 2020. PMID: 32157087 Free PMC article.
Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M, Demircioglu F, Wong PP, Matchett KP, Henderson NC, D'Amico G, Parsons M, Harwood C, Meier P, Hodivala-Dilke KM. Lechertier T, et al. Nat Commun. 2020 Jun 4;11(1):2810. doi: 10.1038/s41467-020-16618-6. Nat Commun. 2020. PMID: 32499572 Free PMC article.
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