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Melanoma brain metastases that progress on BRAF-MEK inhibitors demonstrate resistance to ipilimumab-nivolumab that is associated with the Innate PD-1 Resistance Signature (IPRES).
Lau PKH, Feran B, Smith L, Lasocki A, Molania R, Smith K, Weppler A, Angel C, Kee D, Bhave P, Lee B, Young RJ, Iravani A, Yeang HA, Vergara IA, Kok D, Drummond K, Neeson PJ, Sheppard KE, Papenfuss T, Solomon BJ, Sandhu S, McArthur GA. Lau PKH, et al. Among authors: neeson pj. J Immunother Cancer. 2021 Oct;9(10):e002995. doi: 10.1136/jitc-2021-002995. J Immunother Cancer. 2021. PMID: 34625515 Free PMC article.
The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound.
Shortt J, Hsu AK, Martin BP, Doggett K, Matthews GM, Doyle MA, Ellul J, Jockel TE, Andrews DM, Hogg SJ, Reitsma A, Faulkner D, Bergsagel PL, Chesi M, Heath JK, Denny WA, Thompson PE, Neeson PJ, Ritchie DS, McArthur GA, Johnstone RW. Shortt J, et al. Among authors: neeson pj. Cell Rep. 2014 May 22;7(4):1009-19. doi: 10.1016/j.celrep.2014.04.008. Epub 2014 May 9. Cell Rep. 2014. PMID: 24813887 Free article.
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer.
Dushyanthen S, Teo ZL, Caramia F, Savas P, Mintoff CP, Virassamy B, Henderson MA, Luen SJ, Mansour M, Kershaw MH, Trapani JA, Neeson PJ, Salgado R, McArthur GA, Balko JM, Beavis PA, Darcy PK, Loi S. Dushyanthen S, et al. Among authors: neeson pj. Nat Commun. 2017 Sep 19;8(1):606. doi: 10.1038/s41467-017-00728-9. Nat Commun. 2017. PMID: 28928458 Free PMC article.
133 results