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1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity.
Legru A, Verdirosa F, Hernandez JF, Tassone G, Sannio F, Benvenuti M, Conde PA, Bossis G, Thomas CA, Crowder MW, Dillenberger M, Becker K, Pozzi C, Mangani S, Docquier JD, Gavara L. Legru A, et al. Among authors: thomas ca. Eur J Med Chem. 2021 Dec 15;226:113873. doi: 10.1016/j.ejmech.2021.113873. Epub 2021 Oct 4. Eur J Med Chem. 2021. PMID: 34626878
A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions.
Cheng Z, Shurina BA, Bethel CR, Thomas PW, Marshall SH, Thomas CA, Yang K, Kimble RL, Montgomery JS, Orischak MG, Miller CM, Tennenbaum JL, Nix JC, Tierney DL, Fast W, Bonomo RA, Page RC, Crowder MW. Cheng Z, et al. Among authors: thomas ca, thomas pw. mBio. 2019 Nov 19;10(6):e02412-19. doi: 10.1128/mBio.02412-19. mBio. 2019. PMID: 31744917 Free PMC article.
MBLinhibitors.com, a Website Resource Offering Information and Expertise for the Continued Development of Metallo--Lactamase Inhibitors.
Cheng Z, Thomas CA, Joyner AR, Kimble RL, Sturgill AM, Tran NY, Vulcan MR, Klinsky SA, Orea DJ, Platt CR, Cao F, Li B, Yang Q, Yurkiewicz CJ, Fast W, Crowder MW. Cheng Z, et al. Among authors: thomas ca. Biomolecules. 2020 Mar 16;10(3):459. doi: 10.3390/biom10030459. Biomolecules. 2020. PMID: 32188106 Free PMC article.
Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants.
Cheng Z, Bethel CR, Thomas PW, Shurina BA, Alao JP, Thomas CA, Yang K, Marshall SH, Zhang H, Sturgill AM, Kravats AN, Page RC, Fast W, Bonomo RA, Crowder MW. Cheng Z, et al. Among authors: thomas ca, thomas pw. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e01714-20. doi: 10.1128/AAC.01714-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33468463 Free PMC article.
Visualizing the Dynamic Metalation State of New Delhi Metallo-β-lactamase-1 in Bacteria Using a Reversible Fluorescent Probe.
Mehta R, Rivera DD, Reilley DJ, Tan D, Thomas PW, Hinojosa A, Stewart AC, Cheng Z, Thomas CA, Crowder MW, Alexandrova AN, Fast W, Que EL. Mehta R, et al. Among authors: thomas ca, thomas pw. J Am Chem Soc. 2021 Jun 9;143(22):8314-8323. doi: 10.1021/jacs.1c00290. Epub 2021 May 26. J Am Chem Soc. 2021. PMID: 34038127 Free PMC article.
385 results