Gynther M - Search Results

1

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality.

Kiander W, Vellonen KS, Malinen MM, Gynther M, Hagström M, Bhattacharya M, Auriola S, Koenderink JB, Kidron H. Kiander W, et al. Among authors: gynther m. Pharm Res. 2021 Oct;38(10):1663-1675. doi: 10.1007/s11095-021-03107-8. Epub 2021 Oct 13. Pharm Res. 2021. PMID: 34647232 Free PMC article.

2

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.

Peura L, Malmioja K, Huttunen K, Leppänen J, Hämäläinen M, Forsberg MM, Gynther M, Rautio J, Laine K. Peura L, et al. Among authors: gynther m. Pharm Res. 2013 Oct;30(10):2523-37. doi: 10.1007/s11095-012-0966-3. Pharm Res. 2013. PMID: 24137801

3

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

Vellonen KS, Ihalainen J, Boucau MC, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. Vellonen KS, et al. Among authors: gynther m. Pharm Res. 2017 Dec;34(12):2652-2662. doi: 10.1007/s11095-017-2263-7. Epub 2017 Sep 26. Pharm Res. 2017. PMID: 28952054

4

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist.

Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. Gynther M, et al. J Med Chem. 2017 Dec 14;60(23):9885-9904. doi: 10.1021/acs.jmedchem.7b01624. Epub 2017 Dec 5. J Med Chem. 2017. PMID: 29205034 Free PMC article.

5

Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake.

Kärkkäinen J, Gynther M, Kokkola T, Petsalo A, Auriola S, Lahtela-Kakkonen M, Laine K, Rautio J, Huttunen KM. Kärkkäinen J, et al. Among authors: gynther m. Int J Pharm. 2018 Jun 10;544(1):91-99. doi: 10.1016/j.ijpharm.2018.04.025. Epub 2018 Apr 15. Int J Pharm. 2018. PMID: 29669256

6

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes.

Gynther M, Puris E, Peltokangas S, Auriola S, Kanninen KM, Koistinaho J, Huttunen KM, Ruponen M, Vellonen KS. Gynther M, et al. Pharm Res. 2018 Nov 28;36(1):17. doi: 10.1007/s11095-018-2546-7. Pharm Res. 2018. PMID: 30488131 Free PMC article.

7

L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.

Puris E, Gynther M, Huttunen J, Auriola S, Huttunen KM. Puris E, et al. Among authors: gynther m. Eur J Pharm Sci. 2019 Mar 1;129:99-109. doi: 10.1016/j.ejps.2019.01.002. Epub 2019 Jan 6. Eur J Pharm Sci. 2019. PMID: 30625368

8

Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.

Puris E, Gynther M, de Lange ECM, Auriola S, Hammarlund-Udenaes M, Huttunen KM, Loryan I. Puris E, et al. Among authors: gynther m. Mol Pharm. 2019 Jul 1;16(7):3261-3274. doi: 10.1021/acs.molpharmaceut.9b00502. Epub 2019 Jun 18. Mol Pharm. 2019. PMID: 31180686

9

L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia.

Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. Huttunen J, et al. Among authors: gynther m. Sci Rep. 2019 Sep 6;9(1):12860. doi: 10.1038/s41598-019-49009-z. Sci Rep. 2019. PMID: 31492955 Free PMC article.

10

L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs).

Huttunen J, Gynther M, Vellonen KS, Huttunen KM. Huttunen J, et al. Among authors: gynther m. Int J Pharm. 2019 Nov 25;571:118714. doi: 10.1016/j.ijpharm.2019.118714. Epub 2019 Oct 11. Int J Pharm. 2019. PMID: 31610281

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