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Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase.
Koike T, Constantinescu CC, Ikeda S, Nishi T, Sunahara E, Miyamoto M, Cole P, Barret O, Alagille D, Papin C, Morley T, Fowles K, Seibyl J, Tamagnan G, Kuroita T. Koike T, et al. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1148-1156. doi: 10.1007/s00259-021-05565-z. Epub 2021 Oct 15. Eur J Nucl Med Mol Imaging. 2022. PMID: 34651220 Free PMC article.
Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase.
Hattori Y, Aoyama K, Maeda J, Arimura N, Takahashi Y, Sasaki M, Fujinaga M, Seki C, Nagai Y, Kawamura K, Yamasaki T, Zhang MR, Higuchi M, Koike T. Hattori Y, et al. Among authors: koike t. J Med Chem. 2019 Mar 14;62(5):2362-2375. doi: 10.1021/acs.jmedchem.8b01576. Epub 2019 Feb 26. J Med Chem. 2019. PMID: 30753069
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.
Nishi T, Kondo S, Miyamoto M, Watanabe S, Hasegawa S, Kondo S, Yano J, Watanabe E, Ishi T, Yoshikawa M, Ando HK, Farnaby W, Fujimoto S, Sunahara E, Ohori M, During MJ, Kuroita T, Koike T. Nishi T, et al. Among authors: koike t. Sci Rep. 2020 Oct 13;10(1):17081. doi: 10.1038/s41598-020-74036-6. Sci Rep. 2020. PMID: 33051477 Free PMC article.
Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain.
Hattori Y, Matsuda S, Baba R, Matsumiya K, Iwasaki S, Constantinescu CC, Morley TJ, Carroll VM, Papin C, Gouasmat A, Alagille D, Tamagnan G, Koike T. Hattori Y, et al. Among authors: koike t. J Med Chem. 2021 Apr 8;64(7):3780-3793. doi: 10.1021/acs.jmedchem.0c01937. Epub 2021 Mar 17. J Med Chem. 2021. PMID: 33729758
Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain.
Hattori Y, Yamasaki T, Ohashi T, Miyanohana Y, Kusumoto T, Maeda R, Miyamoto M, Debori Y, Hata A, Zhang Y, Wakizaka H, Wakabayashi T, Fujinaga M, Yamashita R, Zhang MR, Koike T. Hattori Y, et al. Among authors: koike t. J Med Chem. 2021 Aug 26;64(16):11990-12002. doi: 10.1021/acs.jmedchem.1c00584. Epub 2021 Aug 4. J Med Chem. 2021. PMID: 34347478
Design, Synthesis, and Evaluation of [18F]T-914 as a Novel Positron-Emission Tomography Tracer for Lysine-Specific Demethylase 1.
Matsuda S, Hattori Y, Matsumiya K, McQuade P, Yamashita T, Aida J, Sandiego CM, Gouasmat A, Carroll VM, Barret O, Tamagnan G, Koike T, Kimura H. Matsuda S, et al. Among authors: koike t. J Med Chem. 2021 Sep 9;64(17):12680-12690. doi: 10.1021/acs.jmedchem.1c00653. Epub 2021 Aug 23. J Med Chem. 2021. PMID: 34423983 Free article.
2,640 results