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Vitiligo Skin T Cells Are Prone to Produce Type 1 and Type 2 Cytokines to Induce Melanocyte Dysfunction and Epidermal Inflammatory Response Through Jak Signaling.
Martins C, Migayron L, Drullion C, Jacquemin C, Lucchese F, Rambert J, Merhi R, Michon P, Taieb A, Rezvani HR, de Rinaldis E, Seneschal J, Boniface K. Martins C, et al. J Invest Dermatol. 2022 Apr;142(4):1194-1205.e7. doi: 10.1016/j.jid.2021.09.015. Epub 2021 Oct 14. J Invest Dermatol. 2022. PMID: 34655610 Free article.
Vitiligo Skin Is Imprinted with Resident Memory CD8 T Cells Expressing CXCR3.
Boniface K, Jacquemin C, Darrigade AS, Dessarthe B, Martins C, Boukhedouni N, Vernisse C, Grasseau A, Thiolat D, Rambert J, Lucchese F, Bertolotti A, Ezzedine K, Taieb A, Seneschal J. Boniface K, et al. Among authors: martins c. J Invest Dermatol. 2018 Feb;138(2):355-364. doi: 10.1016/j.jid.2017.08.038. Epub 2017 Sep 18. J Invest Dermatol. 2018. PMID: 28927891 Free article.
Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo.
Boukhedouni N, Martins C, Darrigade AS, Drullion C, Rambert J, Barrault C, Garnier J, Jacquemin C, Thiolat D, Lucchese F, Morel F, Ezzedine K, Taieb A, Bernard FX, Seneschal J, Boniface K. Boukhedouni N, et al. Among authors: martins c. JCI Insight. 2020 Jun 4;5(11):e133772. doi: 10.1172/jci.insight.133772. JCI Insight. 2020. PMID: 32369451 Free PMC article.
Complete response in a patient with advanced melanoma following anti-PD-1 therapy is associated with a high frequency of melanoma-infiltrating CXCR3+ resident memory CD8+ T cells and multiple chemokine pathways.
Dousset L, Martins C, Jacquemin C, Amico S, Schatton T, Boniface K, Seneschal J. Dousset L, et al. Among authors: martins c. Br J Dermatol. 2021 Sep;185(3):663-666. doi: 10.1111/bjd.20405. Epub 2021 Jun 14. Br J Dermatol. 2021. PMID: 33894001 No abstract available.
Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint blockade.
Holzgruber J, Martins C, Kulcsar Z, Duplaine A, Rasbach E, Migayron L, Singh P, Statham E, Landsberg J, Boniface K, Seneschal J, Hoetzenecker W, Berdan EL, Ho Sui S, Ramsey MR, Barthel SR, Schatton T. Holzgruber J, et al. Among authors: martins c. Nat Commun. 2024 Aug 26;15(1):7165. doi: 10.1038/s41467-024-51496-2. Nat Commun. 2024. PMID: 39187481 Free PMC article.
Tumor cell-intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling.
Martins C, Rasbach E, Heppt MV, Singh P, Kulcsar Z, Holzgruber J, Chakraborty A, Mucciarone K, Kleffel S, Brandenburg A, Hoetzenecker W, Rahbari NN, DeCaprio JA, Thakuria M, Murphy GF, Ramsey MR, Posch C, Barthel SR, Schatton T. Martins C, et al. Sci Adv. 2024 Jan 19;10(3):eadi2012. doi: 10.1126/sciadv.adi2012. Epub 2024 Jan 19. Sci Adv. 2024. PMID: 38241371 Free PMC article.
2,878 results