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The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus.
Dong W, Mead H, Tian L, Park JG, Garcia JI, Jaramillo S, Barr T, Kollath DS, Coyne VK, Stone NE, Jones A, Zhang J, Li A, Wang LS, Milanes-Yearsley M, Torrelles JB, Martinez-Sobrido L, Keim PS, Barker BM, Caligiuri MA, Yu J. Dong W, et al. Among authors: torrelles jb. J Virol. 2022 Jan 12;96(1):e0096421. doi: 10.1128/JVI.00964-21. Epub 2021 Oct 20. J Virol. 2022. PMID: 34668775 Free PMC article.
Differential Role of Type 2 Diabetes as a Risk Factor for Tuberculosis in the Elderly versus Younger Adults.
Restrepo BI, Scordo JM, Aguillón-Durán GP, Ayala D, Quirino-Cerrillo AP, Loera-Salazar R, Cruz-González A, Caso JA, Joya-Ayala M, García-Oropesa EM, Salinas AB, Martinez L, Schlesinger LS, Torrelles JB, Turner J. Restrepo BI, et al. Among authors: torrelles jb. Pathogens. 2022 Dec 16;11(12):1551. doi: 10.3390/pathogens11121551. Pathogens. 2022. PMID: 36558885 Free PMC article.
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Oladunni FS, Park JG, Pino PA, Gonzalez O, Akhter A, Allué-Guardia A, Olmo-Fontánez A, Gautam S, Garcia-Vilanova A, Ye C, Chiem K, Headley C, Dwivedi V, Parodi LM, Alfson KJ, Staples HM, Schami A, Garcia JI, Whigham A, Platt RN 2nd, Gazi M, Martinez J, Chuba C, Earley S, Rodriguez OH, Mdaki SD, Kavelish KN, Escalona R, Hallam CRA, Christie C, Patterson JL, Anderson TJC, Carrion R Jr, Dick EJ Jr, Hall-Ursone S, Schlesinger LS, Alvarez X, Kaushal D, Giavedoni LD, Turner J, Martinez-Sobrido L, Torrelles JB. Oladunni FS, et al. Among authors: torrelles jb. Nat Commun. 2020 Nov 30;11(1):6122. doi: 10.1038/s41467-020-19891-7. Nat Commun. 2020. PMID: 33257679 Free PMC article.
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets.
Singh DK, Singh B, Ganatra SR, Gazi M, Cole J, Thippeshappa R, Alfson KJ, Clemmons E, Gonzalez O, Escobedo R, Lee TH, Chatterjee A, Goez-Gazi Y, Sharan R, Gough M, Alvarez C, Blakley A, Ferdin J, Bartley C, Staples H, Parodi L, Callery J, Mannino A, Klaffke B, Escareno P, Platt RN 2nd, Hodara V, Scordo J, Gautam S, Vilanova AG, Olmo-Fontanez A, Schami A, Oyejide A, Ajithdoss DK, Copin R, Baum A, Kyratsous C, Alvarez X, Ahmed M, Rosa B, Goodroe A, Dutton J, Hall-Ursone S, Frost PA, Voges AK, Ross CN, Sayers K, Chen C, Hallam C, Khader SA, Mitreva M, Anderson TJC, Martinez-Sobrido L, Patterson JL, Turner J, Torrelles JB, Dick EJ Jr, Brasky K, Schlesinger LS, Giavedoni LD, Carrion R Jr, Kaushal D. Singh DK, et al. Among authors: torrelles jb. Nat Microbiol. 2021 Jan;6(1):73-86. doi: 10.1038/s41564-020-00841-4. Epub 2020 Dec 18. Nat Microbiol. 2021. PMID: 33340034 Free PMC article.
Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2.
Plante KS, Dwivedi V, Plante JA, Fernandez D, Mirchandani D, Bopp N, Aguilar PV, Park JG, Tamayo PP, Delgado J, Shivanna V, Torrelles JB, Martinez-Sobrido L, Matos R, Weaver SC, Sastry KJ, Newman RA. Plante KS, et al. Among authors: torrelles jb. Biomed Pharmacother. 2021 Jun;138:111457. doi: 10.1016/j.biopha.2021.111457. Epub 2021 Mar 3. Biomed Pharmacother. 2021. PMID: 33721754 Free PMC article.
SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern induce lethal disease in K18-hACE2 transgenic mice despite convalescent plasma therapy.
Horspool AM, Ye C, Wong TY, Russ BP, Lee KS, Winters MT, Bevere JR, Kieffer T, Martinez I, Sourimant J, Greninger A, Plemper RK, Denvir J, Cyphert HA, Torrelles J, Martinez-Sobrido L, Damron FH. Horspool AM, et al. bioRxiv [Preprint]. 2021 May 5:2021.05.05.442784. doi: 10.1101/2021.05.05.442784. bioRxiv. 2021. PMID: 33972945 Free PMC article. Preprint.
Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice.
Silvas JA, Vasquez DM, Park JG, Chiem K, Allué-Guardia A, Garcia-Vilanova A, Platt RN, Miorin L, Kehrer T, Cupic A, Gonzalez-Reiche AS, Bakel HV, García-Sastre A, Anderson T, Torrelles JB, Ye C, Martinez-Sobrido L. Silvas JA, et al. Among authors: torrelles jb. J Virol. 2021 Aug 10;95(17):e0040221. doi: 10.1128/JVI.00402-21. Epub 2021 Aug 10. J Virol. 2021. PMID: 34133899 Free PMC article.
Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2.
Park JG, Oladunni FS, Rohaim MA, Whittingham-Dowd J, Tollitt J, Hodges MDJ, Fathallah N, Assas MB, Alhazmi W, Almilaibary A, Iqbal M, Chang P, Escalona R, Shivanna V, Torrelles JB, Worthington JJ, Jackson-Jones LH, Martinez-Sobrido L, Munir M. Park JG, et al. Among authors: torrelles jb. iScience. 2021 Sep 24;24(9):102941. doi: 10.1016/j.isci.2021.102941. Epub 2021 Aug 4. iScience. 2021. PMID: 34368648 Free PMC article.
142 results