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Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension.
Negi V, Yang J, Speyer G, Pulgarin A, Handen A, Zhao J, Tai YY, Tang Y, Culley MK, Yu Q, Forsythe P, Gorelova A, Watson AM, Al Aaraj Y, Satoh T, Sharifi-Sanjani M, Rajaratnam A, Sembrat J, Provencher S, Yin X, Vargas SO, Rojas M, Bonnet S, Torrino S, Wagner BK, Schreiber SL, Dai M, Bertero T, Al Ghouleh I, Kim S, Chan SY. Negi V, et al. Among authors: schreiber sl. Sci Adv. 2021 Oct 22;7(43):eabh3794. doi: 10.1126/sciadv.abh3794. Epub 2021 Oct 20. Sci Adv. 2021. PMID: 34669463 Free PMC article.
Large-scale chemical dissection of mitochondrial function.
Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK. Wagner BK, et al. Among authors: schreiber sl. Nat Biotechnol. 2008 Mar;26(3):343-51. doi: 10.1038/nbt1387. Epub 2008 Feb 24. Nat Biotechnol. 2008. PMID: 18297058 Free PMC article.
Small-molecule inducers of insulin expression in pancreatic alpha-cells.
Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Fomina-Yadlin D, et al. Among authors: schreiber sl. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104. doi: 10.1073/pnas.1010018107. Epub 2010 Aug 9. Proc Natl Acad Sci U S A. 2010. PMID: 20696901 Free PMC article.
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.
Kubicek S, Gilbert JC, Fomina-Yadlin D, Gitlin AD, Yuan Y, Wagner FF, Holson EB, Luo T, Lewis TA, Taylor B, Gupta S, Shamji AF, Wagner BK, Clemons PA, Schreiber SL. Kubicek S, et al. Among authors: schreiber sl. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5364-9. doi: 10.1073/pnas.1201079109. Epub 2012 Mar 20. Proc Natl Acad Sci U S A. 2012. PMID: 22434908 Free PMC article.
558 results