Alford JS - Search Results

1

Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.

Lampe JW, Alford JS, Boriak-Sjodin PA, Brach D, Cosmopoulos K, Duncan KW, Eckley ST, Foley MA, Harvey DM, Motwani V, Munchhof MJ, Raimondi A, Riera TV, Tang C, Thomenius MJ, Totman J, Farrow NA. Lampe JW, et al. Among authors: alford js. ACS Med Chem Lett. 2021 Aug 24;12(10):1539-1545. doi: 10.1021/acsmedchemlett.1c00272. eCollection 2021 Oct 14. ACS Med Chem Lett. 2021. PMID: 34671445 Free PMC article.

2

Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies.

Alford JS, Lampe JW, Brach D, Chesworth R, Cosmopoulos K, Duncan KW, Eckley ST, Kutok JL, Raimondi A, Riera TV, Shook B, Tang C, Totman J, Farrow NA. Alford JS, et al. ACS Med Chem Lett. 2022 Jun 7;13(7):1137-1143. doi: 10.1021/acsmedchemlett.2c00167. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859865 Free PMC article.

3

Aspartyl Oxidation Catalysts That Dial In Functional Group Selectivity, along with Regio- and Stereoselectivity.

Alford JS, Abascal NC, Shugrue CR, Colvin SM, Romney DK, Miller SJ. Alford JS, et al. ACS Cent Sci. 2016 Oct 26;2(10):733-739. doi: 10.1021/acscentsci.6b00237. Epub 2016 Sep 13. ACS Cent Sci. 2016. PMID: 27800556 Free PMC article.

4

Asymmetric Cyclopropanation with 4-Aryloxy-1-sulfonyl-1,2,3-triazoles: Expanding the Range of Rhodium-Stabilized Donor/Acceptor Carbenes to Systems with an Oxygen Donor Group.

Kubiak RW 2nd, Tracy WF, Alford JS, Davies HML. Kubiak RW 2nd, et al. Among authors: alford js. J Org Chem. 2022 Nov 4;87(21):13517-13528. doi: 10.1021/acs.joc.2c00978. Epub 2022 Oct 20. J Org Chem. 2022. PMID: 36264239 Free PMC article.

5

Expanding the scope of donor/acceptor carbenes to N-phthalimido donor groups: diastereoselective synthesis of 1-cyclopropane α-amino acids.

Alford JS, Davies HM. Alford JS, et al. Org Lett. 2012 Dec 7;14(23):6020-3. doi: 10.1021/ol3029127. Epub 2012 Nov 15. Org Lett. 2012. PMID: 23153274

6

Reactions of metallocarbenes derived from N-sulfonyl-1,2,3-triazoles.

Davies HM, Alford JS. Davies HM, et al. Among authors: alford js. Chem Soc Rev. 2014 Aug 7;43(15):5151-62. doi: 10.1039/c4cs00072b. Chem Soc Rev. 2014. PMID: 24802192

7

Conversion of cyclic ketones to 2,3-fused pyrroles and substituted indoles.

Alford JS, Spangler JE, Davies HM. Alford JS, et al. J Am Chem Soc. 2013 Aug 14;135(32):11712-5. doi: 10.1021/ja405043g. Epub 2013 Aug 5. J Am Chem Soc. 2013. PMID: 23915171

8

Guide to Enantioselective Dirhodium(II)-Catalyzed Cyclopropanation with Aryldiazoacetates.

Chepiga KM, Qin C, Alford JS, Chennamadhavuni S, Gregg TM, Olson JP, Davies HM. Chepiga KM, et al. Among authors: alford js. Tetrahedron. 2013 Jul 8;69(27-28):10.1016/j.tet.2013.04.075. doi: 10.1016/j.tet.2013.04.075. Tetrahedron. 2013. PMID: 24273349 Free PMC article.

9

Mild aminoacylation of indoles and pyrroles through a three-component reaction with ynol ethers and sulfonyl azides.

Alford JS, Davies HM. Alford JS, et al. J Am Chem Soc. 2014 Jul 23;136(29):10266-9. doi: 10.1021/ja5058967. Epub 2014 Jul 15. J Am Chem Soc. 2014. PMID: 24998910

10

Enantioselective Intermolecular C-H Functionalization of Allylic and Benzylic sp(3) C-H Bonds Using N-Sulfonyl-1,2,3-triazoles.

Kubiak RW 2nd, Mighion JD, Wilkerson-Hill SM, Alford JS, Yoshidomi T, Davies HM. Kubiak RW 2nd, et al. Among authors: alford js. Org Lett. 2016 Jul 1;18(13):3118-21. doi: 10.1021/acs.orglett.6b01298. Epub 2016 Jun 22. Org Lett. 2016. PMID: 27333162 Free PMC article.

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