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Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr).
Rajamani S, Anderson CL, Valdivia CR, Eckhardt LL, Foell JD, Robertson GA, Kamp TJ, Makielski JC, Anson BD, January CT. Rajamani S, et al. Among authors: eckhardt ll. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1278-88. doi: 10.1152/ajpheart.00777.2005. Epub 2005 Oct 14. Am J Physiol Heart Circ Physiol. 2006. PMID: 16227340 Free article.
Genetic Loss of IK1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia.
Reilly L, Alvarado FJ, Lang D, Abozeid S, Van Ert H, Spellman C, Warden J, Makielski JC, Glukhov AV, Eckhardt LL. Reilly L, et al. Among authors: eckhardt ll. Circ Arrhythm Electrophysiol. 2020 Sep;13(9):e008638. doi: 10.1161/CIRCEP.120.008638. Epub 2020 Aug 4. Circ Arrhythm Electrophysiol. 2020. PMID: 32931337 Free PMC article.
Long QT Syndrome KCNH2 Variant Induces hERG1a/1b Subunit Imbalance in Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Feng L, Zhang J, Lee C, Kim G, Liu F, Petersen AJ, Lim E, Anderson CL, Orland KM, Robertson GA, Eckhardt LL, January CT, Kamp TJ. Feng L, et al. Among authors: eckhardt ll. Circ Arrhythm Electrophysiol. 2021 Apr;14(4):e009343. doi: 10.1161/CIRCEP.120.009343. Epub 2021 Mar 17. Circ Arrhythm Electrophysiol. 2021. PMID: 33729832 Free PMC article.
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