O'Meara TR - Search Results

1

A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.

MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie NM, Todd RT, Stogios PJ, Sanchez H, O'Meara TR, Tompkins TA, Savchenko A, Selmecki A, Veri AO, Andes DR, Fidel PL Jr, Robbins N, Nodwell J, Whitesell L, Cowen LE. MacAlpine J, et al. Nat Commun. 2021 Oct 22;12(1):6151. doi: 10.1038/s41467-021-26390-w. Nat Commun. 2021. PMID: 34686660 Free PMC article.

2

Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence.

O'Meara TR, Cowen LE. O'Meara TR, et al. Cell Microbiol. 2014 Apr;16(4):473-81. doi: 10.1111/cmi.12266. Epub 2014 Feb 14. Cell Microbiol. 2014. PMID: 24438186 Review.

3

Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug Combinations.

Hill JA, O'Meara TR, Cowen LE. Hill JA, et al. Cell Rep. 2015 Feb 10;10(5):809-819. doi: 10.1016/j.celrep.2015.01.009. Epub 2015 Feb 5. Cell Rep. 2015. PMID: 25660029 Free article.

4

Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies.

Polvi EJ, Li X, O'Meara TR, Leach MD, Cowen LE. Polvi EJ, et al. Cell Mol Life Sci. 2015 Jun;72(12):2261-87. doi: 10.1007/s00018-015-1860-z. Epub 2015 Feb 21. Cell Mol Life Sci. 2015. PMID: 25700837 Free PMC article. Review.

5

Global analysis of fungal morphology exposes mechanisms of host cell escape.

O'Meara TR, Veri AO, Ketela T, Jiang B, Roemer T, Cowen LE. O'Meara TR, et al. Nat Commun. 2015 Mar 31;6:6741. doi: 10.1038/ncomms7741. Nat Commun. 2015. PMID: 25824284 Free PMC article.

6

Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress.

O'Meara TR, Veri AO, Polvi EJ, Li X, Valaei SF, Diezmann S, Cowen LE. O'Meara TR, et al. PLoS Genet. 2016 Jun 24;12(6):e1006142. doi: 10.1371/journal.pgen.1006142. eCollection 2016 Jun. PLoS Genet. 2016. PMID: 27341673 Free PMC article.

7

Extensive functional redundancy in the regulation of Candida albicans drug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31.

Li X, Robbins N, O'Meara TR, Cowen LE. Li X, et al. Mol Microbiol. 2017 Feb;103(4):635-656. doi: 10.1111/mmi.13578. Epub 2016 Dec 14. Mol Microbiol. 2017. PMID: 27868254 Free PMC article.

8

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A.

Xie JL, O'Meara TR, Polvi EJ, Robbins N, Cowen LE. Xie JL, et al. mSphere. 2017 Mar 1;2(2):e00056-17. doi: 10.1128/mSphere.00056-17. eCollection 2017 Mar-Apr. mSphere. 2017. PMID: 28261668 Free PMC article.

9

The Hsp90 Chaperone Network Modulates Candida Virulence Traits.

O'Meara TR, Robbins N, Cowen LE. O'Meara TR, et al. Trends Microbiol. 2017 Oct;25(10):809-819. doi: 10.1016/j.tim.2017.05.003. Epub 2017 May 23. Trends Microbiol. 2017. PMID: 28549824 Free PMC article. Review.

10

Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes.

Maxson ME, Naj X, O'Meara TR, Plumb JD, Cowen LE, Grinstein S. Maxson ME, et al. Elife. 2018 Mar 19;7:e34798. doi: 10.7554/eLife.34798. Elife. 2018. PMID: 29553370 Free PMC article.

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