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Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment.
Tan YM, Barton HA, Boobis A, Brunner R, Clewell H, Cope R, Dawson J, Domoradzki J, Egeghy P, Gulati P, Ingle B, Kleinstreuer N, Lowe K, Lowit A, Mendez E, Miller D, Minucci J, Nguyen J, Paini A, Perron M, Phillips K, Qian H, Ramanarayanan T, Sewell F, Villanueva P, Wambaugh J, Embry M. Tan YM, et al. Among authors: wambaugh j. Regul Toxicol Pharmacol. 2021 Dec;127:105070. doi: 10.1016/j.yrtph.2021.105070. Epub 2021 Oct 28. Regul Toxicol Pharmacol. 2021. PMID: 34718074 Free PMC article.
Modeling single and repeated dose pharmacokinetics of PFOA in mice.
Lou I, Wambaugh JF, Lau C, Hanson RG, Lindstrom AB, Strynar MJ, Zehr RD, Setzer RW, Barton HA. Lou I, et al. Among authors: wambaugh jf. Toxicol Sci. 2009 Feb;107(2):331-41. doi: 10.1093/toxsci/kfn234. Epub 2008 Nov 12. Toxicol Sci. 2009. PMID: 19005225
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS. Rotroff DM, et al. Among authors: wambaugh jf. Toxicol Sci. 2010 Oct;117(2):348-58. doi: 10.1093/toxsci/kfq220. Epub 2010 Jul 16. Toxicol Sci. 2010. PMID: 20639261 Free PMC article.
Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.
Wetmore BA, Wambaugh JF, Ferguson SS, Li L, Clewell HJ 3rd, Judson RS, Freeman K, Bao W, Sochaski MA, Chu TM, Black MB, Healy E, Allen B, Andersen ME, Wolfinger RD, Thomas RS. Wetmore BA, et al. Among authors: wambaugh jf. Toxicol Sci. 2013 Apr;132(2):327-46. doi: 10.1093/toxsci/kft012. Epub 2013 Jan 28. Toxicol Sci. 2013. PMID: 23358191
159 results