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The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
J Exp Med. 2021 Dec 6;218(12):e20202012. doi: 10.1084/jem.20202012. Epub 2021 Nov 2.
J Exp Med. 2021.
PMID: 34726730
Free PMC article.
GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1.
Choi S, Hatzihristidis T, Gaud G, Dutta A, Lee J, Arya A, Clubb LM, Stamos DB, Markovics A, Mikecz K, Love P.
Choi S, et al. Among authors: clubb lm.
J Exp Med. 2023 Jul 3;220(7):e20221649. doi: 10.1084/jem.20221649. Epub 2023 Apr 17.
J Exp Med. 2023.
PMID: 37067793
Free PMC article.
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THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1.
Choi S, Lee J, Hatzihristidis T, Gaud G, Dutta A, Arya A, Clubb LM, Stamos DB, Markovics A, Mikecz K, Love PE.
Choi S, et al. Among authors: clubb lm.
Sci Signal. 2023 May 9;16(784):eade1274. doi: 10.1126/scisignal.ade1274. Epub 2023 May 9.
Sci Signal. 2023.
PMID: 37159521
Free PMC article.
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The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure.
Wu VH, Yung BS, Faraji F, Saddawi-Konefka R, Wang Z, Wenzel AT, Song MJ, Pagadala MS, Clubb LM, Chiou J, Sinha S, Matic M, Raimondi F, Hoang TS, Berdeaux R, Vignali DAA, Iglesias-Bartolome R, Carter H, Ruppin E, Mesirov JP, Gutkind JS.
Wu VH, et al. Among authors: clubb lm.
Nat Immunol. 2023 Aug;24(8):1318-1330. doi: 10.1038/s41590-023-01529-7. Epub 2023 Jun 12.
Nat Immunol. 2023.
PMID: 37308665
Free PMC article.
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